Oct 18, 1996

Hippocampal age-related changes in schizophrenia: a proton magnetic resonance spectroscopy study

Schizophrenia Research
M Maier, M A Ron

Abstract

We have used proton magnetic resonance spectroscopy to study in vivo N-acetyl aspartate (NAA), choline and creatine in the hippocampi of 26 schizophrenics and 38 normal controls. Measurements of NAA suggest that age-related neuronal loss occurs at a similar rate in schizophrenics and controls. On the other hand, we observe in schizophrenics age-related choline abnormalities not present in controls. We suggest that these age-related changes may be related to an abnormal myelination process and contribute to the observed clinical deterioration associated with schizophrenia.

  • References51
  • Citations24

References

Mentioned in this Paper

Choline
N-acetylaspartate
Schizophrenia
Aspartic Acid, Magnesium-Potassium (2:1:2) Salt
Nerve Degeneration
Senility
Creatine
Teens
Neuronal
Ambidexterity

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