Hippocampal atrophy and functional connectivity disruption in cirrhotic patients with minimal hepatic encephalopathy

Metabolic Brain Disease
Weiwen LinHua-Jun Chen

Abstract

The hippocampus is a crucial pathological node for minimal hepatic encephalopathy (MHE) and it is associated with various cognitive impairments. Investigations on alterations involving hippocampal morphology and functional connectivity (FC) in MHE are limited. This study aimed to simultaneously evaluate hippocampal volume and FC alterations and their association with cognitive decline in MHE. Twenty-two cirrhotic patients with MHE, 31 cirrhotic patients without MHE (NHE), and 43 healthy controls underwent high-resolution T1-weighted imaging, resting-state functional magnetic resonance imaging, and cognition assessment based on Psychometric Hepatic Encephalopathy Score (PHES). The structural images were preprocessed using a voxel-based morphometry method, during which hippocampal volume was measured. The hippocampal connectivity network was identified using seed-based correlation analysis. Hippocampal volume and FC strength were compared across the three groups and correlated against the PHES results of the cirrhotic patients. Compared to the controls, MHE patients exhibited a significantly lower bilateral hippocampal volume. A slight decrease in hippocampal volume was obtained from NHE to MHE, but it did not reach statistically...Continue Reading

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Citations

Nov 28, 2020·Brain Imaging and Behavior·Sule TinazMichael L Schilsky
Feb 9, 2021·Frontiers in Cellular and Infection Microbiology·Zefeng ChenGuobin Wu
Mar 16, 2021·Frontiers in Neuroanatomy·Hua-Jun ChenRong Chen
May 26, 2021·Journal of Magnetic Resonance Imaging : JMRI·Shiwei LinYingwei Qiu

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Software Mentioned

DARTEL
SPM Assistant
Statistical Parametric Mapping SPM8
DPARSF
SPM8

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