Hippocampal atrophy is related to impaired memory, but not frontal functions in non-demented Parkinson's disease patients

Neuroreport
P RiekkinenM Riekkinen

Abstract

We investigated the neuropsychological correlates of hippocampal atrophy in Parkinson's disease (PD) patients. The memory impaired PD patients had smaller hippocampi than other PD patients. The performance of PD patients in spatial working memory and attentional set-shifting correlated with the severity of motor defect, and not with hippocampal atrophy. Our results suggests that failure of verbal/visual memory may be related to hippocampal atrophy in Parkinson's disease. On the contrast, the defect in spatial working memory and attentional set-shifting may be sensitive to dysfunction of 'fronto-striatal' systems in PD patients.

References

Jan 1, 1986·Annual Review of Neuroscience·G E AlexanderP L Strick
May 1, 1967·Neurology·M M Hoehn, M D Yahr
Feb 1, 1957·Journal of Neurology, Neurosurgery, and Psychiatry·W B SCOVILLE, B MILNER

❮ Previous
Next ❯

Citations

Feb 24, 2007·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Alain Dagher, Atsuko Nagano-Saito
Sep 23, 2003·Brain Research. Brain Research Reviews·Szabolcs Kéri
Jul 19, 2006·Stem Cells and Development·Wendy PhillipsRoger A Barker
May 1, 2007·Regenerative Medicine·Barbara SteinerGerd Kempermann
Nov 28, 2013·Journal of Exercise Rehabilitation·Han-Sam ChoChang-Ju Kim
Aug 20, 2004·QJM : Monthly Journal of the Association of Physicians·P K Panegyres
Mar 17, 2010·Neuromolecular Medicine·Jesse E HansonDaniel V Madison
Jun 15, 2004·Nature Neuroscience·Günter U HöglingerEtienne C Hirsch
Sep 24, 2015·Expert Review of Neurotherapeutics·Paolina PantchevaCesar V Borlongan
Dec 3, 2008·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Vasilios StergiouAnna Karlovasitou
Jun 20, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Richard CamicioliJeffrey A Kaye
Oct 31, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Naroa Ibarretxe-BilbaoMaria-Jose Marti
Jun 2, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M CotelliA Padovani
Aug 8, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Bàrbara SeguraCarme Junque
Jun 5, 2010·Brain Pathology·Lisa C Silbert, Jeffrey Kaye
Jul 21, 2015·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Nicola M J EdelstynAndrew R Mayes
Jul 28, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Napatr SriraksaKowit Chaisiwamongkol
Aug 26, 2011·Journal of the Neurological Sciences·Naroa Ibarretxe-BilbaoEduardo Tolosa
Jan 29, 2014·Parkinsonism & Related Disorders·Takaaki WakamoriIsao Date
Aug 22, 2013·Journal of Neurodevelopmental Disorders·Diane MullinsDeclan G Murphy
Jun 6, 2018·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Cindy Chi-Ching PangRaymond Chuen-Chung Chang
Mar 26, 2002·Brain : a Journal of Neurology·N J CordatoJ G L Morris

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.