Hippocampal (CA1) activities in Wistar rats from different vendors. Fundamental differences in acute ischemia

Journal of Neuroscience Methods
Máté MarosiJózsef Toldi

Abstract

Two-vessel occlusion, a frequently used model of global cerebral ischemia in rats, results in a dysfunction predominantly within the CA1 field of the hippocampus; it induces many processes with different time-scales. However, the great divergence in the results of the studies reported in the literature suggests valuable differences in response to hypoperfusion-induced ischemia among the laboratory rats used in these studies. In the present work, the acute effects of two-carotid occlusion-induced global ischemia (2VO) on the CA3 stimulation-evoked population spike activity in the CA1 region of Wistar rats from different suppliers (Charles-River and Harlan) were compared. In the acute electrophysiological experiments, the hippocampal CA1 responses revealed that the Charles-River rats immediately compensated the 2VO much better than did the Harlan rats. However, 3 days later, no difference could be observed between the CA1 activities of these rats. The presented data show that the Wistar rats from different vendors represent an important source of variability in the results of acute experiments on the hippocampal ischemia. These observations draw attention to the importance of the careful choice of the laboratory rats (both strain...Continue Reading

References

Nov 1, 1977·Archives of Neurology·W D HeissJ Bruck
Mar 1, 1987·The Journal of Physiology·N FujiwaraM Yoshimura
May 1, 1988·Japanese Journal of Medicine·F YoshidaM Fujishima
Dec 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·P CelsisJ P Marc-Vergnes
Sep 1, 1966·The Anatomical Record·J O Brown
Feb 28, 1997·Neuroscience Letters·J C de la TorreF Gonzalez-Lima
Nov 6, 2002·Journal of the Neurological Sciences·Cristina SartiDomenico Inzitari
Apr 26, 2003·Acta Physiologica Scandinavica·B Sampaio-MaiaM Pestana

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Citations

Sep 8, 2010·Neurochemistry International·Gutiérrez-Vargas JohannaCardona-Gómez Gloria Patricia
Dec 26, 2015·Biochimica Et Biophysica Acta·Alex M Helman, M Paul Murphy
May 14, 2014·Neurourology and Urodynamics·Ching-Chung LiangTsong-Hai Lee
Dec 3, 2011·Neurobiology of Aging·Akihiro KitamuraMasafumi Ihara
Jun 5, 2015·Frontiers in Aging Neuroscience·Javier G Villamil-Ortiz, Gloria P Cardona-Gomez
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Akihiro KitamuraMasafumi Ihara
Sep 17, 2016·Clinical Science·Trevor HardiganAdviye Ergul
Mar 3, 2020·Nutritional Neuroscience·P A Pérez-CorredorG P Cardona-Gómez
Jul 7, 2021·Neurochemistry International·Mahmoud I YoussefWei-Wei Hu

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