Hippocampal CA1 gamma power predicts the precision of spatial memory judgments

Proceedings of the National Academy of Sciences of the United States of America
Rebecca F StevensonMichael A Yassa

Abstract

The hippocampus plays a critical role in spatial memory. However, the exact neural mechanisms underlying high-fidelity spatial memory representations are unknown. We report findings from presurgical epilepsy patients with bilateral hippocampal depth electrodes performing an object-location memory task that provided a broad range of spatial memory precision. During encoding, patients were shown a series of objects along the circumference of an invisible circle. At test, the same objects were shown at the top of the circle (0°), and patients used a dial to move the object to its location shown during encoding. Angular error between the correct location and the indicated location was recorded as a continuous measure of performance. By registering pre- and postimplantation MRI scans, we were able to localize the electrodes to specific hippocampal subfields. We found a correlation between increased gamma power, thought to reflect local excitatory activity, and the precision of spatial memory retrieval in hippocampal CA1 electrodes. Additionally, we found a similar relationship between gamma power and memory precision in the dorsolateral prefrontal cortex and a directional relationship between activity in this region and in the CA1, ...Continue Reading

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Citations

May 3, 2019·Journal of Neurotrauma·Sherveen N ParivashMichael Zeineh
Sep 12, 2020·Journal of Neural Engineering·Elizabeth L JohnsonRobert T Knight
Jun 17, 2020·Neurobiology of Learning and Memory·Kamin KimCharan Ranganath
Mar 17, 2021·Attention, Perception & Psychophysics·Vladislava SegenJan M Wiener
Jul 21, 2021·Brain Stimulation·Jiali LiuLiang Wang
Aug 19, 2021·Journal of Cognitive Neuroscience·Saana M KorkkiJon S Simons

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