PMID: 8592201Nov 1, 1995Paper

Hippocampal CA1 lacunosum-moleculare interneurons: modulation of monosynaptic GABAergic IPSCs by presynaptic GABAB receptors

Journal of Neurophysiology
R KhazipovY Ben-Ari

Abstract

1. Whole cell patch-clamp recordings were employed to characterize monosynaptic inhibitory postsynaptic currents (IPSCs) in morphologically and electrophysiologically identified interneurons located in the stratum lacunosum moleculare, or near the border of the stratum radiatum (LM interneurons), in the CA1 region of hippocampal slices taken from 3- to 4-wk-old rats. Monosynaptic IPSCs, evoked in the presence of glutamate receptor antagonists 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; 20 microM) and D-2-amino-5-phosphopentanoate (APV; 50 microM) were biphasic. The gamma-aminobutyric acid-A (GABAA) receptor antagonist, bicuculline (20 microM), blocked the fast IPSC, and the slow IPSC was blocked by the GABAB receptor antagonist CGP35348 (500 microM). 2. Monosynaptic IPSCs were evoked by electrical stimulation in several distant regions including the stratum radiatum, the stratum oriens, the stratum lacunosum-moleculare, and the molecular layer of dentate gyrus, suggesting an extensive network of inhibitory interneurons in the hippocampus. In paired recordings of CA1 interneurons and pyramidal cells, IPSCs were evoked by electrical stimulation of most of these distal regions with the exception of the molecular layer of dentate g...Continue Reading

Citations

Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Nov 21, 1998·The European Journal of Neuroscience·B Sutor, H J Luhmann
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·M FrerkingR A Nicoll
Apr 5, 2008·The Journal of Physiology·Eduardo CalixtoGermán Barrionuevo
Aug 8, 2018·Cell and Tissue Research·Sam A Booker, Imre Vida
Mar 4, 2000·The Journal of Physiology·L JiangJ Kang
Jul 21, 2005·The European Journal of Neuroscience·Christian PatenaudeJean-Claude Lacaille
Nov 13, 2004·The Journal of Physiology·Peter Somogyi, Thomas Klausberger
Sep 9, 2009·The European Journal of Neuroscience·Thomas Klausberger
Oct 16, 2009·Hippocampus·Kathleen E CosgroveGermán Barrionuevo
Jul 13, 2002·The Journal of Comparative Neurology·Alberto MuñozJavier DeFelipe
Jul 21, 2015·Nature Reviews. Neuroscience·Linda Overstreet-Wadiche, Chris J McBain
Sep 29, 2017·Physiological Reviews·Kenneth A PelkeyChris J McBain
Sep 14, 1999·Journal of Neurophysiology·C J Wierenga, W J Wadman
Sep 14, 1999·Journal of Neurophysiology·D D MottD V Lewis
Dec 7, 2007·Neuron·György BuzsákiMarcus Raichle

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.