Hippocampal cell proliferation and epileptogenesis after audiogenic kindling are not accompanied by mossy fiber sprouting or Fluoro-Jade staining

Neuroscience
R N Romcy-Pereira, N Garcia-Cairasco

Abstract

Repetitive sound-induced seizures, known as audiogenic kindling (AK), gradually induce the transference of epileptic activity from brainstem to forebrain structures along with behavioral changes. The aim of our work was to correlate the behavioral changes observed during the AK with possible alterations in neuronal proliferation, cell death, hippocampal mossy fiber sprouting and in the EEG pattern of Wistar audiogenic rats, a genetically susceptible strain from our laboratory. Susceptible and non-susceptible animals were submitted to repeated sound stimulations for 14-16 days and hippocampal mitotic activity was studied through the incorporation of bromodeoxyuridine (BrdU). Cell death and mossy fiber sprouting were assessed, respectively, by using Fluoro-Jade and Timm staining, 2 and 32 days after the last kindling stimulation. In addition, we used immunofluorescent double labeling for a glial and a mitotic marker to evaluate newly born cell identity. Some animals had hippocampus and amygdala electrodes for EEG recordings. Our results show that kindled animals with 6-11 generalized limbic seizures (class IV-V) had increased cell proliferation in the dentate gyrus when compared with animals with zero or one to three seizures. Br...Continue Reading

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Citations

Apr 7, 2007·Bulletin of Experimental Biology and Medicine·T A SavinaT G Shchipakina
May 24, 2012·Neuroscience and Biobehavioral Reviews·Radwa A B BadawyAnthony S Harvey
Oct 18, 2008·Epilepsy & Behavior : E&B·Rodrigo N Romcy-PereiraNorberto Garcia-Cairasco
Oct 5, 2011·The European Journal of Neuroscience·André FisahnBarbara Canlon
Nov 14, 2012·Epilepsy & Behavior : E&B·Julián TejadaNorberto Garcia-Cairasco
Jun 11, 2010·Clinical Science·Marilia G A G PereiraClaudio M Costa-Neto
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Oct 28, 2016·The Journal of Physiology·Leonardo T TotolaThiago S Moreira
Feb 17, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·N Garcia-Cairasco
Sep 24, 2004·Neuroscience Letters·Lucas Henrique Maia MagalhãesMárcio Flávio Dutra Moraes
Oct 16, 2007·Journal of Neuroscience Methods·Rodrigo N Romcy-PereiraNorberto Garcia-Cairasco
May 17, 2017·Epilepsy & Behavior : E&B·Norberto Garcia-CairascoJosé A Cortes de Oliveira
May 21, 2018·The European Journal of Neuroscience·Alexandra Olimpio Siqueira CunhaRicardo Maurício Leão
Jun 22, 2018·Systems Biology in Reproductive Medicine·Eduardo H UmeokaPaula A Navarro
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Apr 15, 2020·International Journal of Neural Systems·Rodrigo F O PenaAlexandra Olimpio Siqueira Cunha
Oct 22, 2019·Frontiers in Neurology·Carlos Roberto Porto DechandtLuciane Carla Alberici
Jan 8, 2021·Frontiers in Behavioral Neuroscience·Willian Lazarini-LopesNorberto Garcia-Cairasco
Jan 20, 2020·Neuroscience and Biobehavioral Reviews·Willian Lazarini-LopesNorberto Garcia-Cairasco
Feb 9, 2021·Frontiers in Behavioral Neuroscience·Giselda Cabral-PereiraRicardo Gómez-Nieto
Jan 12, 2021·Frontiers in Neuroscience·Christiane BecariMarilia G A G Pereira
Jan 18, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Amanda Larissa Dias PachecoOlagide Wagner de Castro
Mar 2, 2021·Frontiers in Behavioral Neuroscience·Willian Lazarini-LopesNorberto Garcia-Cairasco
Apr 23, 2021·Epilepsy & Behavior : E&B·Willian Lazarini-LopesNorberto Garcia-Cairasco

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