Hippocampal choline acetyltransferase activity correlates with spatial learning in aged rats

Brain Research
G L DunbarL R Williams

Abstract

Age-related cognitive deficits in both humans and experimental animals appear to relate to dysfunction of basal forebrain cholinergic neuron systems. The present study assessed spatial learning performance in a water maze task as a function of choline acetyltransferase and high-affinity choline uptake specific activity (the two phenotypic markers for cholinergic neurons) in frontal cortex, hippocampus and striatum of aged male Fischer-344 rats. We observed that increased hippocampal choline acetyltransferase activity was related to better performance on the water maze task, and that, of the individual measures, hippocampal choline acetyltransferase activity was the best predictor of behavioral performance in the spatial learning task.

References

Jan 29, 1990·Brain Research·M C AltavistaA Albanese
Sep 1, 1989·The International Journal of Neuroscience·R BrandeisS Yehuda
Jan 1, 1985·Neurobiology of Aging·J C HornbergerP D Coleman
Jan 1, 1981·Neurobiology of Aging·D K IngramC L Goodrick
Jan 1, 1984·Progress in Biophysics and Molecular Biology·S Tucek
Jan 1, 1981·Annual Review of Pharmacology and Toxicology·L R Squire, H P Davis
Jul 30, 1982·Science·R T BartusA S Lippa
Aug 7, 1981·Science·G E GibsonD J Jenden
Jan 1, 1980·Neurobiology of Aging·A S LippaR T Bartus
Oct 1, 1981·Journal of Neurochemistry·G E Gibson, C Peterson
Jan 1, 1989·The European Journal of Neuroscience·Walter FischerAnders Björklund

❮ Previous
Next ❯

Citations

Nov 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M OkadaM Fujiwara
Feb 1, 1996·Psychopharmacology·N HooperT W Stone
Nov 5, 2003·Clinical and Experimental Hypertension : CHE·J Michael WyssThomas van Groen
Feb 28, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M VirgiliA Contestabile
Jul 1, 1995·Neuroscience·I AubertR Quirion
Dec 18, 1995·Brain Research·T ArakiY Itoyama

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.