Hippocampal connexin 43 expression in human complex partial seizure disorder

Experimental Neurology
K ElisevichK Edvardsen

Abstract

An increase in the cellular production of gap junction proteins and increased numbers of gap junctions in the neuronoglial syncytium of an epileptic focus have been proposed as a possible mechanism underlying synchronization of discharge. To study this issue, both Northern and Western blot analyses of the gap junction protein connexin 43 mRNA and protein abundance were performed on hippocampal tissue resected from patients presenting with a complex partial seizure disorder arising from the medial temporal area and the hippocampus in particular. Samples from 15 patients with medically intractable seizures were compared to those from 5 nonepileptic patients requiring temporal lobectomy in life-threatening situations. Six of the 15 epileptic patients underwent noninvasive electrographic recording, whereas the remaining 9 patients required intracerebral electrodes for extraoperative recording and therefore showed a more discrete focality than the noninvasive recordings. A decline in the mean levels of connexin 43 mRNA expressed predominantly in astrocytes was noted in the epileptic patient groups, particularly for those cases requiring intracranial electrode placement where ictal onset was more clearly established to be intrahippoc...Continue Reading

References

Oct 1, 1992·Trends in Neurosciences·M Chesler, K Kaila
Jul 1, 1992·The Journal of Cell Biology·A C CharlesM J Sanderson
Jun 1, 1992·Neuron·S Finkbeiner
May 1, 1992·Journal of Neurosurgery·I FriedD D Spencer
Feb 1, 1991·Experimental Neurology·C C NausD L Paul
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D ZhuC C Naus
Aug 28, 1989·Brain Research·N C de LanerolleD D Spencer
Jan 1, 1985·Teratogenesis, Carcinogenesis, and Mutagenesis·C M JoneC C Chang
May 30, 1973·Brain Research·F L Glötzner
Feb 1, 1982·Brain Research Bulletin·R D AndrewF E Dudek
Sep 8, 1980·Brain Research·B A MacVicar, F E Dudek
Apr 22, 1982·Brain Research·B A MacVicarK Krnjevic
May 1, 1993·Trends in Neurosciences·R Dermietzel, D C Spray
Jun 30, 1994·Nature·V ParpuraP G Haydon

❮ Previous
Next ❯

Citations

Mar 23, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Eliseo A EugeninJoan W Berman
Mar 9, 2011·Neuroscience Letters·Jeffrey A Loeb
Feb 16, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Siamak BeheshtiBehrouz Vaziri
Jan 17, 2015·Neuroscience·C SteinhäuserG Carmignoto
May 23, 2014·Frontiers in Physiology·Shanthini MylvaganamPeter L Carlen
Jan 27, 2017·BMC Cell Biology·Andrei B BelousovChristian C Naus
Mar 29, 2018·PLoS Computational Biology·Mengmeng DuYing Wu
May 16, 2002·Journal of Cellular Physiology·Antonio De MaioJorge E Contreras
Jan 23, 1998·Molecular and Chemical Neuropathology·K ElisevichN Allar
Oct 10, 2019·Glia·Peter BednerChristian Steinhäuser
Nov 24, 2011·Neuroscience Bulletin·Miao-Miao Jin, Zhong Chen
Aug 12, 2000·Journal of Neurophysiology·J S SchweitzerJ L Stringer
Oct 5, 2002·Journal of Neurophysiology·Shokrollah S JahromiPeter L Carlen
Mar 13, 2014·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Vincenzo CrunelliChristian Steinhäuser
Nov 26, 2020·Biomolecules·Laura WalraveIlse Smolders
Apr 7, 2000·Brain Research. Brain Research Reviews·J I Nagy, J E Rash
Aug 2, 2002·European Journal of Pharmacology·Christian Steinhäuser, Gerald Seifert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.