Hippocampal-dependent memory is impaired in heterozygous GAP-43 knockout mice

Hippocampus
Jerome L RekartAryeh Routtenberg

Abstract

Cajal proposed that the rearrangement and growth of neurites and synaptic terminals is a substrate for the formation and storage of long-term memories. Proteins that regulate this learning-dependent growth are therefore likely to be "core determinants" (Sanes and Lichtman, Nat Neurosci 1999; 2:597-604) of such information storage processes. Although the growth-associated, protein kinase C (PKC) substrate GAP-43 has been oft-implicated in synaptic plasticity and memory, it has never been demonstrated that a reduction in the level of this protein has a deleterious effect on memory, because most homozygotes die perinatally. In this report, we observe significant memory impairments in heterozygous GAP-43 knockout mice with GAP-43 levels reduced by one-half. Impaired memory for a context was demonstrated in contextual fear conditioning. Importantly, no significant impairments in cued conditioning or on tests of nociceptive or auditory perception were observed in the heterozygous knockout, indicating that the observed impairments were unlikely related to performance or acquisition factors and are the result of reduced GAP-43 levels in the hippocampus. The present results, taken together with the prior demonstration of enhanced memory...Continue Reading

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Citations

Jun 8, 2007·Learning & Memory·Matthew R HolahanAryeh Routtenberg
Feb 3, 2006·Environmental Health Perspectives·Henrik AlmMichael Stigson
Mar 22, 2014·PloS One·Nicole Rosskothen-Kuhl, Robert-Benjamin Illing
Dec 15, 2015·Molecular Biology of the Cell·Kathryn R WilliamsGary J Bassell
Apr 12, 2008·European Journal of Pharmacology·Thomas J NelsonDaniel L Alkon
Dec 23, 2006·Neurobiology of Learning and Memory·Federico BolognaniEdwin J Weeber
Oct 10, 2006·Journal of Neuroendocrinology·C von SchassenG M Rune
Nov 1, 2007·Journal of Neurochemistry·Kristof Van KolenFrank M Dautzenberg
May 9, 2012·Journal of Neurochemistry·Gustavo P GuerraMaribel A Rubin
Oct 12, 2012·Cell Biochemistry and Function·Shoko Morita, Seiji Miyata
Nov 10, 2009·Archiv der Pharmazie·Miao-Kun Sun, Daniel L Alkon
Oct 19, 2005·Neurobiology of Learning and Memory·Craig M Powell
Jun 28, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hasina AkhterRui-Ming Liu
Dec 7, 2013·The Tohoku Journal of Experimental Medicine·Nozomi OnoderaIsato Araki
Jul 13, 2019·Experimental Physiology·Marjan ErfaniAva Nasrolahi
Jun 22, 2007·Journal of Neurophysiology·Michael J AlbrightMichael C Crair
Oct 6, 2020·Frontiers in Cell and Developmental Biology·Daayun ChungGabriela Caraveo
Jul 28, 2017·Laboratory animal research·Shikha YadavVijay Pal Singh
Jun 20, 2007·Neurochemical Research·Federico BolognaniNora I Perrone-Bizzozero
Aug 21, 2012·Learning & Memory·Karsten Baumgärtel, Isabelle M Mansuy

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