Hippocampal dynorphin immunoreactivity increases in response to gonadal steroids and is positioned for direct modulation by ovarian steroid receptors.

Neuroscience
Annelyn Torres-ReveronTeresa A Milner

Abstract

The hippocampal formation (HF) is involved in modulating learning related to drug abuse. While HF-dependent learning is regulated by both endogenous opioids and estrogen, the interaction between these two systems is not well understood. The mossy fiber (MF) pathway formed by dentate gyrus (DG) granule cell axons is involved in some aspects of learning and contains abundant amounts of the endogenous opioid peptide dynorphin (DYN). To examine the influence of ovarian steroids on DYN expression, we used quantitative light microscopic immunocytochemistry to measure DYN levels in normal cycling rats as well as in two established models of hormone-treated ovariectomized (OVX) rats. Rats in estrus had increased levels of DYN-immunoreactivity (ir) in the DG and certain CA3 lamina compared with rats in proestrus or diestrus. OVX rats exposed to estradiol for 24 h showed increased DYN-ir in the DG and CA3, while those with 72 h estradiol exposure showed increases only in the DG. Six hours of estradiol exposure produced no change in DYN-ir. OVX rats chronically implanted with medroxyprogesterone also showed increased DYN-ir in the DG and CA3. Next, dual-labeling electron microscopy (EM) was used to evaluate the subcellular relationships o...Continue Reading

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Citations

Nov 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Attila I GulyásNorbert Hájos
Jan 7, 2016·Frontiers in Neuroscience·Elena H Chartoff, Maria Mavrikaki
Jan 13, 2011·Neurobiology of Learning and Memory·Tanya J WilliamsTeresa A Milner
Sep 30, 2010·Peptides·Richard J Bodnar
Dec 23, 2009·Hormones and Behavior·Annabell C SegarraYvonne M Torres-Diaz
Jun 10, 2009·Experimental Neurology·Annelyn Torres-ReveronTeresa A Milner
Apr 15, 2017·Behavioural Brain Research·Dinah L Ramos-OrtolazaAnnelyn Torres-Reveron
Nov 22, 2016·Journal of Neuroscience Research·Bruce S McEwen, Teresa A Milner
Nov 22, 2016·Journal of Neuroscience Research·Helen E Scharfman, Neil J MacLusky
Sep 27, 2019·Frontiers in Behavioral Neuroscience·Raura Doreste-MendezAnnelyn Torres-Reveron
May 28, 2019·Neuroscience and Biobehavioral Reviews·E R VelascoR Andero

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