Hippocampal function is compromised in an animal model of multiple sclerosis

Neuroscience
Tanja NovkovicDenise Manahan-Vaughan

Abstract

Multiple sclerosis (MS) is a progressive inflammatory autoimmune disease that is characterized by demyelination and axonal damage in the nervous system. One obvious consequence is a cumulative loss of muscle control. However, cognitive dysfunction affects roughly half of MS sufferers, sometimes already early in the disease course. Although long-term (remote) memory is typically unaffected, the ability to form new declarative memories becomes compromised. A major structure for the encoding of new declarative memories is the hippocampus. Encoding is believed to be mediated by synaptic plasticity in the form of long-term potentiation (LTP) and long-term depression (LTD) of synaptic strength. Here, in an animal model of MS we explored whether disease symptoms are accompanied by a loss of functional neuronal integrity, synaptic plasticity, or hippocampus-dependent learning ability. In mice that developed MOG35-55-induced experimental autoimmune encephalomyelitis (EAE), passive properties of CA1 pyramidal neurons were unaffected, although the ability to fire action potentials became reduced in the late phase of EAE. LTP remained normal in the early phase of MOG35-55-induced EAE. However, in the late phase, LTP was impaired and LTP-re...Continue Reading

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Citations

Dec 5, 2015·Frontiers in Psychology·Jon-Ruben van Rhijn, Sonja C Vernes
Jun 24, 2016·Journal of Neuroinflammation·Nikoo GhaffarianAli Gorji
Feb 13, 2020·International Journal of Molecular Sciences·So Yeong CheonBon-Nyeo Koo
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Aug 16, 2021·Brain, Behavior, and Immunity·Francesca Romana RizzoAntonietta Gentile

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