Hippocampal gene expression changes during age-related cognitive decline

Brain Research
Traci L PawlowskiMatthew J Huentelman

Abstract

As humans age, cognitive performance decreases differentially across individuals. This age-related decline in otherwise healthy individuals is likely due to the interaction of multiple factors including genetics and environment. We hypothesized that altered spatial memory performance in genetically similar mice could be in part due to differential gene expression patterns in the hippocampus. To investigate this we utilized Morris water maze (MWM) testing in a group of young (3 months) and aged (24 months) C57BL/J male mice. Two sub-groups were identified in the aged animals; one in which MWM performance was not significantly different when compared to the young animals (aged-unimpaired; "AU") and one in which performance was significantly different by 1.5 standard deviations from the mean (aged-impaired; "AI"). One week after testing was completed the entire hippocampus was collected from six each of AU, AI and young mice and their gene expression profiles were compared using Affymetrix microarrays. Benjamini and Hochberg FDR correction at p<0.05 identified 18 genes differentially expressed between the AI and AU mice. The correlation between behavioral deficits and gene expression patterning allows a better understanding of how...Continue Reading

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Citations

May 19, 2010·Journal of Neurosurgical Anesthesiology·George BarretoRona G Giffard
Sep 15, 2010·Life Sciences·Sunita SharmaHolly Brown-Borg
Nov 17, 2009·Neurobiology of Aging·Rebecca P HabermanMichela Gallagher
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Feb 28, 2015·Experimental Aging Research·Rubén Sánchez-HorcajoJosé Manuel Cimadevilla
Nov 29, 2014·Frontiers in Cellular Neuroscience·Roman M StillingAndre Fischer
Jul 30, 2015·PloS One·Marissa J SchaferStephen D Ginsberg
Dec 15, 2012·Experimental Biology and Medicine·Delphine PreissmannArmand Savioz
Sep 25, 2020·International Journal of Molecular Sciences·Samantha D CreightonIva B Zovkic

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