Hippocampal IGF-1 expression, neurogenesis and slowed aging: clues to longevity from mutant mice.

Age
Liou Y Sun

Abstract

Recent studies point out the important role of IGF and insulin-related signaling pathways in the control of longevity of laboratory animals. The Ames dwarf mouse is a murine model of circulating GH and IGF-1 deficiency that exhibits dwarf phenotype characteristics and significantly extends lifespan. It is interesting to know that Ames dwarf mice do not experience an age-related decline in cognitive function when compared to their young counterparts. In this study, the most recent works on local GH and IGF-1 expression in the hippocampus of Ames mice are briefly reviewed.

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Citations

Oct 30, 2013·Nursing Research·Jesús Díez-ManglanoJavier Gomes-Martín
Jan 11, 2013·Nursing Research·Michael SimonNancy Dunton
Mar 5, 2016·Frontiers in Neuroscience·Vanesa Nieto-EstévezCarlos Vicario-Abejón
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May 16, 2015·Neural Plasticity·Marco MainardiClaudio Grassi
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Jul 26, 2011·Physiology & Behavior·Adam DerenneSerena Lackman
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Aug 17, 2019·Frontiers in Neuroscience·Matteo SpinelliClaudio Grassi
Mar 5, 2021·The World Journal of Men's Health·Andrzej BartkeMichal M Masternak

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