Hippocampal information processing across sleep/wake cycles

Neuroscience Research
Kenji Mizuseki, Hiroyuki Miyawaki

Abstract

According to a two-stage memory consolidation model, during waking theta states, afferent activity from the neocortex to the hippocampus induces transient synaptic modification in the hippocampus, where the information is deposited as a labile form of memory trace. During subsequent sharp-wave ripples (SPW-Rs), the newly acquired hippocampal information is transferred to the neocortex and stored as a long-lasting memory trace. Consistent with this hypothesis, waking theta states and SPW-Rs distinctly control information flow in the hippocampal-entorhinal loop. Although both waking theta states and rapid eye movement (REM) sleep are characterized by prominent hippocampal theta oscillations, the two brain states involve distinct temporal coordination and oscillatory coupling in the hippocampal-entorhinal circuit. While distinct brain states have distinct network dynamics, firing rates of individual neurons in the hippocampal-entorhinal circuitry follow lognormal-like distributions in all states. Firing rates of the same neurons are positively correlated across brain states and testing environments, suggesting that memory is allocated in preconfigured, rather than tabula rasa-type, skewed neuronal networks. The fast-firing minorit...Continue Reading

Citations

Jul 29, 2018·Cellular and Molecular Life Sciences : CMLS·Daniel G Almeida-FilhoSidarta Ribeiro
Feb 17, 2018·Cell and Tissue Research·Oliver von Bohlen Und Halbach, Viola von Bohlen Und Halbach
Dec 1, 2019·The Journal of Comparative Neurology·Arantxa Blasco-SerraAlfonso A Valverde-Navarro
May 1, 2019·Frontiers in Neuroscience·Erin Munro KrullTaro Toyoizumi
Aug 31, 2017·Fundamental & Clinical Pharmacology·Luis Rafael L SampaioSilvânia M M Vasconcelos
Oct 20, 2020·Frontiers in Neuroscience·Bryce A Mander
Jan 15, 2020·Current Neuropharmacology·Mortimer Mamelak
Dec 4, 2019·Brain Research Bulletin·A BroncelJ Konopacki
Mar 5, 2021·Communications Biology·Jannik Luboeinski, Christian Tetzlaff

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