Hippocampal Injections of Oligomeric Amyloid β-peptide (1-42) Induce Selective Working Memory Deficits and Long-lasting Alterations of ERK Signaling Pathway

Frontiers in Aging Neuroscience
Pierre FaucherDaniel J Beracochea

Abstract

Increasing evidence suggests that abnormal brain accumulation of soluble rather than aggregated amyloid-β1-42 oligomers (Aβo(1-42)) plays a causal role in Alzheimer's disease (AD). However, as yet, animal's models of AD based on oligomeric amyloid-β1-42 injections in the brain have not investigated their long-lasting impacts on molecular and cognitive functions. In addition, the injections have been most often performed in ventricles, but not in the hippocampus, in spite of the fact that the hippocampus is importantly involved in memory processes and is strongly and precociously affected during the early stages of AD. Thus, in the present study, we investigated the long-lasting impacts of intra-hippocampal injections of oligomeric forms of Aβo(1-42) on working and spatial memory and on the related activation of ERK1/2. Indeed, the extracellular signal-regulated kinase (ERK) which is involved in memory function had been found to be activated by amyloid peptides. We found that repeated bilateral injections (1injection/day over 4 successive days) of oligomeric forms of Aβo(1-42) into the dorsal hippocampus lead to long-lasting impairments in two working memory tasks, these deficits being observed 7 days after the last injection, w...Continue Reading

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Citations

Oct 12, 2016·Acta Neuropathologica Communications·Sonia MazzitelliMichela Matteoli
Jul 7, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Ding-Siang HuangJung-Yaw Lin
Jan 28, 2017·International Journal of Peptides·Ernesto Flores-Martínez, Fernando Peña-Ortega
Jul 7, 2020·Frontiers in Neuroscience·Yavar JahangardSeyed Javad Mowla
Aug 10, 2019·BioMed Research International·Henriette R FrederiksenKristine Freude
Feb 2, 2021·Frontiers in Neuroscience·Emmanuelle BoscherSébastien S Hébert
Nov 25, 2020·Neurobiology of Aging·Arnold M SalazarJefferson W Kinney

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Methods Mentioned

BETA
protein assay
transmission electron microscopy
transgenic

Software Mentioned

Statview
SAS

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