Hippocampal Interaction With Area 25, but not Area 32, Regulates Marmoset Approach-Avoidance Behavior.

Cerebral Cortex
Chloe U WallisHannah F Clarke

Abstract

Affective disorders are associated with increased sensitivity to negative feedback that influences approach-avoidance decision making. Although neuroimaging studies of these disorders reveal dysregulation in primate cingulate areas 25 and 32 and the anterior hippocampus (aHipp), the causal involvement of these structures and their interaction in the primate brain is unknown. We therefore investigated the effects of localized pharmacological manipulations of areas 25 and 32 and/or the aHipp of the marmoset monkey on performance of an anxiolytic-sensitive instrumental decision-making task in which an approach-avoidance conflict is created by pairing a response with reward and punishment. During control infusions animals avoided punishment, but this bias was reduced by increasing glutamate release within the aHipp or area 32, and inactivation or 5-HT1a antagonism within area 25. Conversely, increasing glutamate release in area 25 enhanced punishment avoidance but, in contrast to previous reports, area 32 and aHipp inactivations had no effect. Simultaneous inactivation or 5-HT1a antagonism within area 25, but not area 32, abolished the reduced punishment avoidance seen after increasing aHipp glutamate. Besides providing causal evid...Continue Reading

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Citations

Jan 3, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Laurel S MorrisJames W Murrough
Dec 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Angela C Roberts, Hannah F Clarke
Oct 18, 2019·Annual Review of Psychology·Angela C. Roberts
Jun 6, 2019·Brain Sciences·Laith AlexanderAngela C Roberts
Nov 7, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bilgehan ÇavdaroğluRutsuko Ito
Aug 4, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Diego A Pizzagalli, Angela C Roberts
Sep 26, 2021·Molecular Psychiatry·Dominik R Bach

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