Hippocampal lesion effects on occasion setting by contextual and discrete stimuli.

Neurobiology of Learning and Memory
Taejib YoonJeansok J Kim

Abstract

Three experiments examined the role of the dorsal hippocampus (dHIPP) in occasion setting with diffuse contextual and discrete light stimuli serving as occasion setters in classical fear conditioning with rats. Both sham-operated and dHIPP-lesioned animals readily learned a L→T+, T- serial feature-positive discrimination in which a light (L) "set the occasion" for reinforcement of a tone (T+). dHIPP-lesioned animals were deficient, however, in acquiring a similar discrimination in which different contexts (A and B) served as occasion setters, i.e., A(T+) and B(T-). The lesioned animals also failed to discriminate between a context in which a tone had been partially reinforced and a context in which no conditioning had taken place, whereas sham-operated animals froze more to the tone in the conditioned context than in the novel context. Collectively, the data indicate that the dorsal hippocampus is important in processing information about the signaling value of contextual, but not discrete, stimuli.

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Citations

Jun 26, 2013·Neurobiology of Learning and Memory·Stephen Maren
Oct 12, 2012·Cognitive, Affective & Behavioral Neuroscience·Hideo SuzukiDeanna M Barch
Sep 21, 2011·Neurobiology of Learning and Memory·Chihiro Sato MatsumotoMakoto Mizunami
Aug 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Eun Joo KimJeansok J Kim
May 1, 2016·Trends in Neurosciences·Blake A Pellman, Jeansok J Kim
Feb 22, 2011·Behavioural Processes·José Lino Oliveira Bueno, Lézio Soares Bueno Júnior
May 3, 2013·Nature Reviews. Neuroscience·Stephen MarenIsrael Liberzon

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