Hippocampal lesion prevents spatial relational learning in adult macaque monkeys.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Pamela Banta LavenexPierre Lavenex

Abstract

The role of the hippocampus in spatial learning and memory has been extensively studied in rodents. Comparable studies in nonhuman primates, however, are few, and findings are often contradictory. This may be attributable to the failure to distinguish between allocentric and egocentric spatial representations in experimental designs. For this experiment, six adult monkeys received bilateral hippocampal ibotenic acid lesions, and six control subjects underwent sham surgery. Freely moving monkeys then foraged for food located in two arrays of three distinct locations among 18 locations distributed in an open-field arena. Multiple goals and four pseudorandomly chosen entrance points precluded the monkeys' ability to rely on an egocentric strategy to identify food locations. Monkeys were tested in two conditions. First, local visual cues marked the food locations. Second, no local cues marked the food locations, so that monkeys had to rely on an allocentric (spatial relational) representation of the environment to discriminate these locations. Both hippocampal-lesioned and control monkeys discriminated the food locations in the presence of local cues. However, in the absence of local cues, control subjects discriminated the food lo...Continue Reading

Citations

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Oct 6, 2012·Cognitive Psychology·Farfalla RibordyPierre Lavenex
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Nov 22, 2008·Neurobiology of Disease·Rajesh KumarRonald M Harper
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Aug 30, 2008·Hippocampus·Pamela Banta Lavenex, Pierre Lavenex
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Oct 31, 2008·The Journal of Comparative Neurology·Pierre LavenexDavid G Amaral
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Jan 18, 2011·Behavioural Brain Research·Pamela Banta LavenexPierre Lavenex
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Mar 3, 2015·Cognitive Psychology·Pamela Banta LavenexPierre Lavenex
Mar 13, 2015·Frontiers in Psychology·Pamela Banta LavenexStefano Vicari

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