Hippocampal levels of phosphorylated protein kinase A (phosphor-S96) are linked to spatial memory enhancement by SGS742

Hippocampus
Berta SunyerGert Lubec

Abstract

Cognitive enhancement by the GABA (B) receptor antagonist SGS742 has been well-documented, but mechanisms of action are not fully elucidated. Previous work has proposed involvement of somatostatin-14 and protein kinase C in cognitive enhancement; phospho-protein kinase A (p-PKA), fyn, and phospho-fyn are known signaling systems for spatial memory. It was the aim of the study to determine hippocampal levels of these proteins following SGS742-treatment and to correlate them with the outcome from the Morris water maze (MWM), represented by the parameter "time spent in the target quadrant" during the probe trial. OF1 mice were used for the experiments and divided into four groups: intraperitoneal SGS742 and saline solution treatment, both, tested in the MWM, and two yoked controls. Six hours following the probe trial, hippocampal protein levels were determined by immunoblotting. In the MWM, time spent in the target quadrant was significantly enhanced by SGS742 treatment. p-PKA levels were significantly increased only in the SGS742-treated group tested in the MWM as compared to saline treatment. In yoked controls, no significant differences in p-PKA levels between SGS742 and saline treatment were observed. Somatostatin-14 levels wer...Continue Reading

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Citations

Jul 7, 2009·Annual Review of Psychology·Szu-Han Wang, Richard G M Morris
Jan 7, 2014·Amino Acids·Wei-Qiang ChenGert Lubec
Jan 28, 2016·Neuroscience and Biobehavioral Reviews·Chelcie F Heaney, Jefferson W Kinney
Jul 18, 2009·Neuropharmacology·Lin LiGert Lubec
Jan 14, 2009·Hippocampus·Julius Paul Pradeep JohnGert Lubec
May 5, 2011·Hippocampus·Sergio D IñiguezCynthia A Crawford
Jul 23, 2013·Pharmacology, Biochemistry, and Behavior·Kushal KumarRahul Deshmukh
Dec 17, 2014·Expert Review of Neurotherapeutics·Atish PrakashAbu Bakar Abdul Majeed
Jan 22, 2009·Journal of Proteome Research·Jae-Kyung MyungGert Lubec
Oct 2, 2009·Journal of Proteome Research·Wei-Qiang ChenGert Lubec

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