PMID: 8606806Nov 1, 1995Paper

Hippocampal long-term depression: arachidonic acid as a potential retrograde messenger

Neuropharmacology
V Y Bolshakov, Steven A Siegelbaum

Abstract

Long-term depression (LTD) was studied in hippocampal slices from neonatal rats at the synapse between CA3 and CA1 pyramidal neurons. The induction of LTD requires the pairing of Ca2+ influx into the postsynaptic CA1 neuron through voltage-gated calcium channels with activation of metabotropic glutamate receptors. The expression of this LTD is at least partly presynaptic, implying the need for a retrograde messenger. We present evidence that arachidonic acid might serve such a function. Thus, arachidonic acid applications simulate LTD whereas blockade of arachidonic acid release inhibits LTD.

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Citations

Nov 14, 1998·Brain Research·E Murillo-RodríguezO Prospéro-García
Jan 16, 1998·European Journal of Pharmacology·H KatsukiN Matsuki
Aug 31, 2001·Progress in Neurobiology·N Kemp, Z I Bashir
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Jul 25, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S WatanabeT Hamazaki
Nov 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Saak V Ovsepian, J Oliver Dolly
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May 30, 2001·Neuropharmacology·P GubelliniP Calabresi
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Aug 20, 2003·The European Journal of Neuroscience·Nathalie Rouach, Roger A Nicoll
Mar 20, 2015·Journal of Neuroscience Research·Tomasz Wójtowicz, Jerzy W Mozrzymas
Jun 18, 2015·Molecular Neurobiology·Yashasvi SuvarnaM C Shivamurthy
Oct 2, 2002·Neuron·Stanislav S ZakharenkoSteven A Siegelbaum
Jun 24, 2010·Biological Psychiatry·Hengxuan YangDomenico Praticò
Jul 27, 2010·Molecular and Cellular Neurosciences·Nobunari SasakiMineko Kengaku
Jun 2, 2000·The Journal of Physiology·L Liu, A R Rittenhouse
Jan 5, 2005·Molecular Psychiatry·P García-Junco-ClementeR Fernández-Chacón
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Nov 29, 1996·The Journal of Biological Chemistry·I Herrero, J Sánchez-Prieto
Feb 11, 1998·Physiological Reviews·R M Fitzsimonds, M M Poo

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