Hippocampal long term potentiation: silent synapses and beyond

Journal of Physiology, Paris
Jean Christophe Poncer

Abstract

Long-term, activity-driven synaptic plasticity allows neuronal networks to constantly and durably adjust synaptic gains between synaptic partners. These processes have been proposed to serve as a substrate for learning and memory. Long-term synaptic potentiation (LTP) has been observed at many central excitatory synapses and perhaps most extensively studied at Schaffer collaterals synapses onto hippocampal CA1 neurons. Multiple contradictory models were proposed to account for this form of LTP. However, recent evidence suggests that some synapses are initially devoid of functional AMPA receptors which can be incorporated during LTP. This new model appears to account for most, but not all, properties of this form of plasticity. Indeed, several mechanisms seem to act in parallel to specifically enhance AMPA-receptor mediated synaptic transmission.

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Citations

Nov 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Haowei ShenPeter W Kalivas
Jun 19, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tairan XingDi-Yun Ruan
Jun 10, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Howard P GoodkinJaideep Kapur
Jan 23, 2013·The Journal of Physiology·Nicolas Le RouxJean Christophe Poncer
Jan 27, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Eduardo BlancoJuan Suárez
Jul 29, 2009·The Journal of Physiology·M T HoC J McBain
Oct 17, 2008·The Journal of Comparative Neurology·Paromita DasElizabeth I Tietz
Oct 26, 2016·Development and Psychopathology·Michael Rutter
Nov 26, 2015·Molecular & Cellular Proteomics : MCP·Natalia BorovokIzhak Michaelevski
May 25, 2005·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ryanne Wiersma-MeemsNaweed I Syed
Mar 8, 2019·Frontiers in Cellular Neuroscience·Etienne CômeSabine Lévi

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