Hippocampal long-term potentiation that is elicited by perforant path stimulation or that occurs in conjunction with spatial learning is tightly controlled by beta-adrenoreceptors and the locus coeruleus

Hippocampus
Niels Hansen, Denise Manahan-Vaughan

Abstract

The noradrenergic system, driven by locus coeruleus (LC) activation, plays a key role in the regulating and directing of changes in hippocampal synaptic efficacy. The LC releases noradrenaline in response to novel experience and LC activation leads to an enhancement of hippocampus-based learning, and facilitates synaptic plasticity in the form of long-term depression (LTD) and long-term potentiation (LTP) that occur in association with spatial learning. The predominant receptor for mediating these effects is the β-adrenoreceptor. Interestingly, the dependency of synaptic plasticity on this receptor is different in the hippocampal subfields whereby in the CA1 in vivo, LTP, but not LTD requires β-adrenoreceptor activation, whereas in the mossy fiber synapse LTP and LTD do not depend on this receptor. By contrast, synaptic plasticity that is facilitated by spatial learning is highly dependent on β-adrenoreceptor activation in both hippocampal subfields. Here, we explored whether LTP induced by perforant-path (pp) stimulation in vivo or that is facilitated by spatial learning depends on β-adrenoreceptors. We found that under both LTP conditions, antagonising the receptors disabled the persistence of LTP. β-adrenoreceptor-antagonism...Continue Reading

References

Apr 1, 1989·Brain Research Bulletin·C HarleyJ C Lacaille
Jan 1, 1985·Experimental Brain Research·D Dahl, J Winson
Feb 15, 1980·The Journal of Comparative Neurology·R LoyR Y Moore
Dec 1, 1993·Trends in Neurosciences·R C Malenka, R A Nicoll
Jun 1, 1995·The European Journal of Neuroscience·A VankovS J Sara
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Jan 1, 1996·Neural Computation·K I Blum, L F Abbott
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·T SeidenbecherD Balschun
Jan 1, 1997·The European Journal of Neuroscience·V KitchiginaS J Sara
Feb 10, 1997·Neuroreport·C R BramhamJ M Sarvey
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·D Manahan-Vaughan, K H Braunewell
Jan 15, 2003·The Journal of Biological Chemistry·Ling PanVsevolod V Gurevich
May 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Anne Kemp, Denise Manahan-Vaughan
Aug 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Susan G WallingCarolyn W Harley
Feb 25, 2005·Behavioral Neuroscience·Inah LeeRaymond P Kesner
Feb 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert A M BrownCarolyn W Harley
Mar 19, 2005·Learning & Memory·Shukhrat UzakovVolker Korz

❮ Previous
Next ❯

Citations

Nov 27, 2015·Brain Research·David Weinshenker, Philip V Holmes
May 18, 2010·Critical Care : the Official Journal of the Critical Care Forum·Niccolò TerrandoMervyn Maze
Oct 12, 2016·Frontiers in Synaptic Neuroscience·Hannah Twarkowski, Denise Manahan-Vaughan
Nov 2, 2016·Frontiers in Synaptic Neuroscience·Luke Y PrinceJack R Mellor
Oct 21, 2017·Brain : a Journal of Neurology·Jacki M RorabaughDavid Weinshenker
Jul 17, 2018·Neural Plasticity·Olga BorodovitsynaDaniel Chandler
Dec 12, 2018·Physiology International·P D LoprinziE Frith
Jun 10, 2017·Neural Plasticity·Olga BorodovitsynaDaniel Chandler
Oct 28, 2017·Frontiers in Computational Neuroscience·Lorenz GönnerFred H Hamker
Nov 5, 2019·Frontiers in Synaptic Neuroscience·Valentyna Dubovyk, Denise Manahan-Vaughan
Sep 19, 2020·Nature Reviews. Neuroscience·Gina R PoeSusan J Sara
Nov 16, 2020·The European Journal of Neuroscience·Tony JamesNathan A Smith
Oct 30, 2020·Frontiers in Pharmacology·Dianne M Perez
Feb 3, 2021·International Journal of Molecular Sciences·Rola A Bekdash
Aug 20, 2021·IBRO Neuroscience Reports·Athina MiliouCostas Papatheodoropoulos
Aug 22, 2021·Behavioural Pharmacology·Stephanie L GrellaDiano F Marrone

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.