Hippocampal Memory Recovery After Acute Stress: A Behavioral, Morphological and Molecular Study

Frontiers in Molecular Neuroscience
Felipe AguayoJenny L Fiedler

Abstract

Several studies have shown that a single exposure to stress may improve or impair learning and memory processes, depending on the timing in which the stress event occurs with relation to the acquisition phase. However, to date there is no information about the molecular changes that occur at the synapse during the stress-induced memory modification and after a recovery period. In particular, there are no studies that have evaluated-at the same time-the temporality of stress and stress recovery period in hippocampal short-term memory and the effects on dendritic spine morphology, along with variations in N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunits. The aim of our study was to take a multidimensional approach to investigate concomitant behavioral, morphological and molecular changes induced by a single restraint stress exposure (2.5 h) and a recovery period of 6 and 24 h in rats. We found that acute stress elicited a reduced preference to explore an object placed in a novel position (a hippocampal-dependent task). These changes were accompanied by increased activity of LIM kinase I (LIMK; an actin-remodeling protein) and increased levels of NR2A subunits of NMDA re...Continue Reading

References

May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·J J KimR F Thompson
Aug 23, 1996·The Journal of Biological Chemistry·M AmanoK Kaibuchi
Mar 22, 2001·Nature Reviews. Neuroscience·L Luo
May 7, 2002·Learning & Memory·Kevin B Baker, Jeansok J Kim
Jul 19, 2002·Neuron·Yanghong MengZhengping Jia
Jul 10, 2003·Trends in Neurosciences·Haruo KasaiHiroyuki Nakahara
Apr 1, 2004·Learning & Memory·Tracey J Shors
Jan 31, 2006·Physiology·Barbara CalabreseShelley Halpain
Mar 4, 2006·Trends in Cognitive Sciences·Marian JoëlsHarm J Krugers
Aug 26, 2006·Science·Jonathan R WhitlockMark F Bear
Mar 16, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gareth R I BarkerE Clea Warburton
May 8, 2007·Neuron·Laura SagliettiMaria Passafaro
Nov 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jeansok J KimHugh T Blair
Nov 6, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lisa Conboy, Carmen Sandi
Feb 19, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kelly A FosterMorgan Sheng
Mar 6, 2010·Annals of the New York Academy of Sciences·Bruce S McEwen, Peter J Gianaros
Sep 8, 2010·Nature Reviews. Neuroscience·Harmen J KrugersLaurent Groc
Jul 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gareth R I Barker, Elizabeth C Warburton
Oct 4, 2011·Current Opinion in Neurobiology·Miquel Bosch, Yasunori Hayashi
Dec 1, 2011·Nature Reviews. Neuroscience·Maurizio PopoliGerard Sanacora
Apr 19, 2012·Cold Spring Harbor Perspectives in Biology·Christian Lüscher, Robert C Malenka
Apr 20, 2012·Frontiers in Molecular Neuroscience·Amanda Wright, Bryce Vissel
Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christine E Taft, Gina G Turrigiano
Apr 15, 2014·Journal of Neuroendocrinology·E T UchoaM B C de Sousa
Aug 19, 2014·Neurobiology of Learning and Memory·Silvia MiddeiHélène Marie
Oct 31, 2014·Neurochemical Research·Yu JinTomoyuki Nishizaki
May 20, 2015·Behavioural Brain Research·Viviana Vargas-LópezMarisol R Lamprea
Aug 20, 2015·Learning & Memory·Eun Joo KimJeansok J Kim
Oct 16, 2015·PloS One·Rasha Refaat MahmmoudGert Lubec

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Methods Mentioned

BETA
ELISA
Protein Assay
GTPases

Key Resources (RRID) Mentioned

AB_476743
AB_477010
AB_2113443
AB_21113732
AB_887730
AB_260391
AB_2491619
AB_1642257
AB_1031185
AB_887750

Software Mentioned

GraphPad Prism
GraphPad

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