Hippocampal metabolic differences implicate distinctions between physical and psychological stress in four rat models of depression

Translational Psychiatry
Lan-Xiang LiuPeng Xie

Abstract

Major depressive disorder (MDD) is a heterogeneous and multi-factorial disorder, and the underlying molecular mechanisms remain largely unknown. However, many studies have indicated that the molecular mechanisms underlying depression in response to different stress may differ. After screening, 28-30 rats were included in each model of depression (chronic unpredictable mild stress (CUMS); learned helplessness (LH); chronic restraint stress (CRS); or social defeat (SD)). Non-targeted gas chromatography-mass spectrometry was used to profile the metabolic changes in the hippocampus. As a result, all four models exhibited significant depression-like behavior. A total of 30, 24, 19, and 25 differential metabolites were identified in the CUMS, LH, CRS, and SD models, respectively. Interestingly, the hierarchical clustering results revealed two patterns of metabolic changes that are characteristic of the response to cluster 1 (CUMS, LH) and cluster 2 (CRS, SD) stress, which represent physical and psychological stress, respectively. Bioinformatic analysis suggested that physical stress was mainly associated with lipid metabolism and glutamate metabolism, whereas psychological stress was related to cell signaling, cellular proliferation,...Continue Reading

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Citations

Jun 6, 2018·Frontiers in Behavioral Neuroscience·Joe Herbert
Apr 8, 2020·Neuropsychiatric Disease and Treatment·Haiyang WangPeng Xie
Jul 3, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Chrismawan ArdiantoJunaidi Khotib
Sep 3, 2021·Molecular Psychiatry·Juncai PuPeng Xie
Oct 8, 2021·Chemical Senses·Anna AthanassiNathalie Mandairon

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Methods Mentioned

BETA
PCA

Software Mentioned

Matlab
SPSS
Ingenuity Pathway Analysis software IPA
SIMCA
IPA
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