Hippocampal MicroRNAs Respond to Administration of Antidepressant Fluoxetine in Adult Mice

International Journal of Molecular Sciences
Nan MiaoTao Sun

Abstract

Current antidepressant treatments to anxiety and depression remain inadequate, burdened by a significant percentage of misuse and drug side-effects, due to unclear mechanisms of actions of antidepressants. To better understand the regulatory roles of antidepressant fluoxetine-related drug reactions, we here investigate changes of expression levels of hippocampal microRNAs (miRNAs) after administration of fluoxetine in normal adult mice. We find that 64 miRNAs showed significant changes between fluoxetine treatment and control groups by analyzing 626 mouse miRNAs. Many miRNAs in response to fluoxetine are involved in neural-related signaling pathways by analyzing miRNA-target gene pairs using the Kyoto encyclopedia of genes and genomes (KEGG) and Gene Ontology (GO). Moreover, miRNAs with altered expression are mainly associated with the repression of the dopaminergic synapse signals, which may affect hippocampal function after fluoxetine treatment. Our results demonstrate that a number of miRNAs respond to antidepressants even in normal mice and may affect target gene expression, which supports the safety consideration of inappropriate treatment and off-label use of antidepressant drugs.

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Citations

Jul 28, 2019·Journal of Neural Transmission·Nicola LopizzoAnnamaria Cattaneo
Mar 1, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Chenggui Miao, Jun Chang

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Methods Mentioned

BETA
reverse transcription PCR
dissection
electrophoresis

Software Mentioned

TargetScan
miRDB
R
R ( R - Foundation for Statistical Computing
Cytoscape

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