Dec 31, 2013

Hippocampal motifs

BioRxiv : the Preprint Server for Biology
Zahra M AghajanM R Mehta

Abstract

Dorsal Hippocampal neurons provide an allocentric map of space[1][1], characterized by three key properties. First, their firing is spatially selective[1][1]–[3][2], termed a rate code. Second, as animals traverse through place fields, neurons sustain elevated firing rates for long periods, however this has received little attention. Third the theta-phase of spikes within this sustained activity varies with animal’s location, termed phase-precession or a temporal code[4][3]–[10][4]. The precise relationship between these properties and the mechanisms governing them are not understood, although distal visual cues (DVC) are thought to be sufficient to reliably elicit them[2][5],[3][2]. Hence, we measured rat CA1 neurons’ activity during random foraging in two-dimensional VR—where only DVC provide consistent allocentric location information— and compared it with their activity in real world (RW). Surprisingly, we found little spatial selectivity in VR. This is in sharp contrast to robust spatial selectivity commonly seen in one-dimensional RW and VR[7][6]–[11][7], or two-dimensional RW[1][1]–[3][2]. Despite this, neurons in VR generated approximately two-second long phase precessing spike sequences, termed “hippocampal motifs”. Mo...Continue Reading

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Clinical Study by Phase
2-Dimensional
Neurons
Spatial Distribution
Aggregation
Sustain
Anatomical Space Structure
Theta Rhythm
Protein Domain
Location

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.