DOI: 10.1101/483115Nov 30, 2018Paper

Hippocampal-neocortical interactions sharpen over time for predictive actions

BioRxiv : the Preprint Server for Biology
Nicholas C HindyNicholas B Turk-Browne


When an action is familiar, we are able to anticipate how it will change the state of the world. These expectations can result from retrieval of action-outcome associations in the hippocampus and the reinstatement of anticipated outcomes in visual cortex. How does this role for the hippocampus in action-based prediction change over time? We used high-resolution fMRI and a dual-training behavioral paradigm to examine how the hippocampus interacts with visual cortex during predictive and nonpredictive actions learned either three days earlier or immediately before the scan. Just-learned associations led to comparable background connectivity between the hippocampus and V1/V2, regardless of whether actions predicted outcomes. However, three-day-old associations led to stronger background connectivity and greater differentiation between neural patterns for predictive vs. nonpredictive actions. Hippocampal prediction may initially reflect indiscriminate binding of co-occurring of events, with action information pruning weaker associations and leading to more selective and accurate predictions over time.

Related Concepts

Cell Differentiation Process
Cerebral Cortex
Hippocampus (Brain)
Visual Cortex
Apical Segmental Vein

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