Hippocampal-neocortical networks differ during encoding and retrieval of relational memory: functional and effective connectivity analyses

Neuropsychologia
C McCormickM P McAndrews

Abstract

Encoding and retrieval of relational information requires interaction between the hippocampus and various neocortical regions, but it is unknown whether the connectivity of hippocampal-neocortical networks is different at input and output stages. To examine this, we conducted a network analysis of event-related fMRI data collected during a face-recognition, remember/know paradigm. Directed analyses in the medial temporal lobe identified a small region in the left hippocampus that showed differential activation for encoding and retrieval of recollected versus familiar items. Multivariate seed partial least squares (PLS) analysis was used to identify brain regions that were functionally connected to this hippocampal region at encoding and retrieval of 'remembered' items. Anatomically based structural equation modeling (SEM) was then used to test for differences in effective connectivity of network nodes between these two memory stages. The SEM analysis revealed a reversal of directionality between the left hippocampus (LHC) and left inferior parietal cortex (LIPC) at encoding and retrieval. During encoding, activation of the LHC had a positive influence on the LIPC, whereas during retrieval the reverse pattern was found, i.e., th...Continue Reading

References

Dec 22, 1994·The Journal of Comparative Neurology·W A Suzuki, D G Amaral
Mar 1, 1996·Cerebral Cortex·G Buzsáki
Sep 10, 2002·Cerebral Cortex·Selene CansinoMichael D Rugg
Jan 22, 2004·Brain and Cognition·Nancy D Chiaravalloti, Guila Glosser
Sep 24, 2004·Hippocampus·C Brock Kirwan, Craig E L Stark
Oct 27, 2004·NeuroImage·Anthony Randal McIntosh, Nancy J Lobaugh
Feb 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Steven E PrinceRoberto Cabeza
Apr 1, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laura L EldridgeBarbara J Knowlton
Jul 19, 2005·Neuropsychologia·Lisa CipolottiTim Shallice
Aug 2, 2005·Trends in Cognitive Sciences·Anthony D WagnerRandy L Buckner
Mar 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elizabeth A Kensinger, Daniel L Schacter
Apr 25, 2006·Hippocampus·Daniela MontaldiAndrew R Mayes
Jun 2, 2006·Journal of Neurophysiology·S M DaselaarR Cabeza
Aug 11, 2006·Journal of Neurophysiology·Justin L VincentRandy L Buckner
Aug 25, 2006·Human Brain Mapping·Andrea B Protzner, Anthony R McIntosh
Nov 14, 2006·Current Opinion in Neurobiology·Lila Davachi
Nov 30, 2006·Neuropsychologia·Chris M BirdLisa Cipolotti
Jan 6, 2007·Cerebral Cortex·Jeffrey D Johnson, Michael D Rugg
Feb 3, 2007·Trends in Cognitive Sciences·Andrew MayesEllen Migo
Apr 10, 2007·Annual Review of Neuroscience·H EichenbaumC Ranganath
Apr 21, 2007·Neuropsychologia·Erin I Skinner, Myra A Fernandes
May 16, 2007·Psychological Review·Patrick ByrneNeil Burgess
Aug 19, 2007·Hippocampus·Timothy J Teyler, Jerry W Rudy
Jul 22, 2008·Nature Reviews. Neuroscience·Roberto CabezaMorris Moscovitch
Oct 14, 2008·Neurobiology of Learning and Memory·Ingrid R Olson, Marian Berryhill
Nov 26, 2008·Neurobiology of Learning and Memory·Melina R Uncapher, Anthony D Wagner
Jun 17, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Demis Hassabis, Eleanor A Maguire
Aug 12, 2009·Neuroreport·Kaia L Vilberg, Michael D Rugg
Oct 9, 2009·Nature Reviews. Neuroscience·Seralynne D VannEleanor A Maguire
Feb 6, 2010·Neuropsychologia·Jennifer J SummerfieldEleanor A Maguire

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Citations

May 27, 2014·Brain and Cognition·Nancy A DennisKristina M Peterson
Apr 4, 2013·Neuroscience and Biobehavioral Reviews·Carol A Seger, Erik J Peterson
Apr 13, 2011·Trends in Cognitive Sciences·John T Wixted, Larry R Squire
Nov 10, 2014·Brain Imaging and Behavior·Christiane S H OedekovenDirk Leube
Dec 5, 2012·Current Opinion in Neurobiology·Michael D Rugg, Kaia L Vilberg
Aug 2, 2016·Neuropsychologia·Jennifer S RabinR Shayna Rosenbaum
Sep 4, 2010·Behavioural Brain Research·Tamar Levav-RabkinHava M Golan
Aug 14, 2015·Journal of Learning Disabilities·Enguo WangYujun Ma
Mar 3, 2018·Frontiers in Behavioral Neuroscience·Joan Guàrdia-OlmosEsteve Gudayol-Ferré
May 4, 2021·Sleep·Courtney A KurinecHans P A Van Dongen

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