Hippocampal nerve growth factor potentiated by 17β-estradiol and involved in allodynia of inflamed TMJ in rat

The Journal of Pain : Official Journal of the American Pain Society
Yu-Wei WuXu-Chen Ma

Abstract

The hippocampus is believed to play an important role in sex-based differences of pain perception. Whether estrogen potentiates allodynia in the inflamed temporomandibular joint (TMJ) through affecting the expressions of pain-related genes in the hippocampus remains largely unknown. Because the nerve growth factor (NGF) is an important gene related to inflammatory pain, we tested whether hippocampal NGF may be involved in TMJ inflammatory pain. Here we showed that the rat hippocampal NGF was upregulated by TMJ inflammation induced by complete Freund adjuvant. NGF upregulation was further potentiated by estradiol in a dose-dependent manner. In contrast, NGF transcription in the amygdala, prefrontal cortex, and thalamus was not affected by TMJ inflammation and estradiol. An intrahippocampal injection of NGF antibody or NGF receptor inhibitor K252a (inhibitor for tropomyosin receptor kinase A, TrkA) reduced the allodynia of inflamed TMJ in proestrous rats. Our data suggest that the hippocampal NGF is involved in estradiol-sensitized allodynia of inflammatory TMJ pain. We report that complete Freund adjuvant-induced temporomandibular joint (TMJ) inflammation upregulated hippocampal nerve growth factor (NGF) expression, and estradio...Continue Reading

References

Nov 1, 1991·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·K MurakamiT Iizuka
Nov 10, 1994·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Y Komatsubara
Mar 1, 1997·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·H A IsraelA Ratcliffe
Feb 14, 1998·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·S Kopp
May 20, 1998·Pharmacology, Biochemistry, and Behavior·F CirulliL Aloe
Aug 14, 1998·Dementia and Geriatric Cognitive Disorders·M Eriksdotter JönhagenL O Wahlund
Nov 18, 1998·Journal of Neuroscience Research·L AibelM V Chao
Jun 1, 2000·Neuroscience Letters·J HaoM Eriksdotter Jönhagen
Oct 7, 2000·Journal of Dental Research·R P HarperL L Bellinger
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·F S Lee, M V Chao
Jul 17, 2001·Cells, Tissues, Organs·M P Warren, J L Fried
Aug 7, 2001·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·D L Bennett
May 22, 2003·Pharmacology, Biochemistry, and Behavior·C A KerinsL L Bellinger
May 21, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lisa M RattinerKerry J Ressler
Oct 30, 2004·The Journal of Comparative Neurology·Jun YanVassilis E Koliatsos
Apr 13, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Nicola LandiMario Bosco
Apr 28, 2005·Neuroscience Letters·Michael A BierlLori G Isaacson
Dec 2, 2005·The EMBO Journal·Xuming ZhangPeter A McNaughton
Apr 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Martin A Bruno, A Claudio Cuello
Apr 20, 2006·JAMA : the Journal of the American Medical Association·Jan Lewis Brandes
Jul 28, 2006·Arthritis and Rheumatism·MaryFran R SowersDavid A Jamadar
Sep 30, 2006·Arthritis and Rheumatism·Dominic J CirilloRobert A Yood

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.