Hippocampal neurochemical markers in bipolar disorder patients following the first-manic episode: A prospective 12-month proton magnetic resonance spectroscopy study

The Australian and New Zealand Journal of Psychiatry
Leonardo E SilveiraLakshmi N Yatham

Abstract

Previous studies reported decreased N-acetyl aspartate and increased Glx (the sum of glutamate plus glutamine) in bipolar disorder. Since these studies included patients at different stages of illness, it is unknown whether these changes have a causal role or a consequence of multiple episodes and treatments. The studies in early-stage bipolar disorder patients have the potential to provide answers to these issues. Therefore, we evaluated N-acetyl aspartate and Glx levels in hippocampi of first-episode bipolar disorder patients and health subjects at baseline and at 12 months, and examined the impact of episode recurrence on these measures. We used single-voxel proton magnetic resonance spectroscopy to compare the hippocampal neurometabolites ( N-acetyl aspartate and Glx) levels between 41 patients with bipolar disorder following recovery from their first-manic episode and 27 matched healthy subjects at recruitment and 12 months later. We also compared N-acetyl aspartate and Glx levels between patients who had a recurrence of a mood episode and those who did not. There was no main effect of either group (diagnosis) or time for hippocampal N-acetyl aspartate and Glx levels in bipolar disorder patients and healthy subjects. We al...Continue Reading

References

Jan 18, 2008·Neuroscience and Biobehavioral Reviews·Flavio KapczinskiRobert M Post

❮ Previous
Next ❯

Citations

Apr 22, 2016·Acta Psychiatrica Scandinavica·I C PassosF Kapczinski

Dec 14, 2019·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Jairo Vinícius PintoLakshmi N Yatham

❮ Previous
Next ❯

Software Mentioned

Freesurfer
FSL
SPSS
FMRIB

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.