Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment

Nature Neuroscience
Dar MeshiRené Hen

Abstract

Environmental enrichment increases adult hippocampal neurogenesis and alters hippocampal-dependent behavior in rodents. To investigate a causal link between these two observations, we analyzed the effect of enrichment on spatial learning and anxiety-like behavior while blocking adult hippocampal neurogenesis. We report that environmental enrichment alters behavior in mice regardless of their hippocampal neurogenic capability, providing evidence that the newborn cells do not mediate these effects of enrichment.

References

Feb 26, 2000·Science·F H Gage
Mar 22, 2001·Nature Reviews. Neuroscience·H van PraagF H Gage
Aug 6, 2002·Nature Medicine·Michelle L MonjeTheo D Palmer
Nov 21, 2002·Hippocampus·Tracey J ShorsElizabeth Gould
Jun 6, 2003·The European Journal of Neuroscience·Jason BrownH Georg Kuhn
Jan 18, 2005·Neuroscience·J S SnyderJ M Wojtowicz
Jan 19, 2005·The European Journal of Neuroscience·Sebastien Couillard-DespresLudwig Aigner
Jan 28, 2005·The European Journal of Neuroscience·Elodie Bruel-JungermanClaire Rampon
Aug 17, 2005·The European Journal of Neuroscience·David DupretDjoher Nora Abrous
Aug 23, 2005·Behavioural Brain Research·Brenda M Elliott, Neil E Grunberg

❮ Previous
Next ❯

Citations

Sep 6, 2007·Cell and Tissue Research·Marta Andres-MachJohn R Fike
Jun 4, 2013·Behavioural Brain Research·Rebecca RavenelleS Tiffany Donaldson
May 4, 2011·Molecular Psychiatry·A SurgetC Belzung
Jul 17, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Maura BoldriniVictoria Arango
Jul 29, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·María Llorens-MartínJosé L Trejo
Jun 29, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vipan K PariharAshok K Shetty
Aug 21, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ofra Ben-Menachem-ZidonRaz Yirmiya
Dec 15, 2007·Nature Protocols·Nohjin KeePaul W Frankland
Apr 13, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kerri A HolickStephanie C Dulawa
Sep 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Andrew S NaylorH Georg Kuhn
Aug 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jin-Xia DaiLin Xu
May 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·Mirna KvajoJoseph A Gogos
Mar 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Tamar LichtEli Keshet
Jun 15, 2007·Journal of Applied Animal Welfare Science : JAAWS·Nikolaos G KostomitsopoulosVera Baumans
Apr 19, 2007·Clinical and Experimental Pharmacology & Physiology·Helen E Grote, Anthony J Hannan
Feb 21, 2007·Genes, Brain, and Behavior·C A PonderA A Palmer
Jan 20, 2007·Science·Helen E Scharfman, Rene Hen
Jun 23, 2010·Cell Communication and Signaling : CCS·Susanne A WolfGerd Kempermann
Jul 12, 2012·Journal of Neuroinflammation·David LiebetanzSimone C Tauber
May 30, 2008·PloS One·David DupretPier Vincenzo Piazza
Feb 18, 2011·PloS One·Georg HagemannChristian Gaser
Dec 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tessa E HartogManfred Gahr
Oct 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wei DengFred H Gage
Feb 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Junko A AraiLarry A Feig

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.