Hippocampal place cell encoding of sloping terrain

Hippocampus
Blake S PorterDavid K Bilkey

Abstract

Effective navigation relies on knowledge of one's environment. A challenge to effective navigation is accounting for the time and energy costs of routes. Irregular terrain in ecological environments poses a difficult navigational problem as organisms ought to avoid effortful slopes to minimize travel costs. Route planning and navigation have previously been shown to involve hippocampal place cells and their ability to encode and store information about an organism's environment. However, little is known about how place cells may encode the slope of space and associated energy costs as experiments are traditionally carried out in flat, horizontal environments. We set out to investigate how dorsal-CA1 place cells in rats encode systematic changes to the slope of an environment by tilting a shuttle box from flat to 15 ° and 25 ° while minimizing external cue change. Overall, place cell encoding of tilted space was as robust as their encoding of flat ground as measured by traditional place cell metrics such as firing rates, spatial information, coherence, and field size. A large majority of place cells did, however, respond to slope by undergoing partial, complex remapping when the environment was shifted from one tilt angle to ano...Continue Reading

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Citations

Jan 10, 2019·Journal of Neurophysiology·Blake S PorterDavid K Bilkey
Mar 27, 2020·Journal of Neurophysiology·Jeffrey S Taube, Michael E Shinder
Feb 6, 2020·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Bernhard Ronacher
Sep 23, 2020·Animal Cognition·Selim Jedidi-AyoubRoddy M Grieves
Apr 30, 2021·Neural Networks : the Official Journal of the International Neural Network Society·Yihong WangRubin Wang

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