Hippocampal place cells show increased sensitivity to changes in the local environment following prefrontal cortex lesions

Cerebral Cortex
Rachel J Kyd, David K Bilkey

Abstract

It has been proposed that the prefrontal cortex modulates neural activity in posterior cortex via inhibitory mechanisms. As a result, damage to the former area may produce disinhibition in posterior regions and increase sensitivity to extraneous information. This hypothesis was investigated by examining how prefrontal cortex lesions affected the firing of hippocampal place cells in freely moving rats. In experiment 1, the positional firing of lesion-group cells was altered to a greater extent than that of control-group cells when objects were introduced into the recording environment. This suggested that place cell firing was overly influenced by local cues in the prefrontal-lesioned animals. In experiment 2 place cells were recorded while rats foraged on a circular track with access to both local and distal multimodal cues. Although the position of place fields in lesion-group cells was not excessively tied to local cues, a greater proportion of the fields lost their spatial selectivity following a rotation of these cues. The cue-related effects were associated with larger extracellular action-potential amplitudes and a greater incidence of burst-firing in lesion-group cells. This finding is consistent with the hypothesis that...Continue Reading

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Citations

Mar 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·James M HymanJeremy K Seamans
Nov 28, 2013·Neurotoxicity Research·Senthilvelan ManoharRichard Salvi
Feb 2, 2008·Cognitive Processing·Elaine Reese, Michael Colombo
Oct 8, 2014·Genes, Brain, and Behavior·R R RozeskeC Herry
Apr 7, 2015·Brain, Behavior, and Immunity·Amy R Wolff, David K Bilkey
Apr 22, 2015·Current Biology : CB·Eun Joo KimJeansok J Kim
Feb 18, 2014·Neurobiology of Learning and Memory·Jai Y Yu, Loren M Frank
Sep 22, 2020·Brain and Neuroscience Advances·Kaori Takehara-Nishiuchi

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