Abstract
Hippocampal activity patterns representing movement trajectories are reactivated in immobility and sleep periods, a process associated with memory recall, consolidation, and decision making. It is thought that only fixed, behaviorally relevant patterns can be reactivated, which are stored across hippocampal synaptic connections. To test whether some generalized rules govern reactivation, we examined trajectory reactivation following non-stereotypical exploration of familiar open-field environments. We found that random trajectories of varying lengths and timescales were reactivated, resembling that of Brownian motion of particles. The animals' behavioral trajectory did not follow Brownian diffusion demonstrating that the exact behavioral experience is not reactivated. Therefore, hippocampal circuits are able to generate random trajectories of any recently active map by following diffusion dynamics. This ability of hippocampal circuits to generate representations of all behavioral outcome combinations, experienced or not, may underlie a wide variety of hippocampal-dependent cognitive functions such as learning, generalization, and planning.
Citations
Aug 24, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gordon B Feld, Jan Born
May 21, 2020·Nature Communications·Guillaume Viejo, Adrien Peyrache
Apr 7, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sam McKenzieDaniel F English
Apr 7, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Liset M de la Prida
Apr 7, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Matthijs A A van der MeerKamran Diba
Apr 7, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David Tingley, Adrien Peyrache
Nov 27, 2019·Nature Neuroscience·Dana Rubi LevyOfer Yizhar
Jul 9, 2020·Neuromolecular Medicine·Peixian HuangYiyu Deng
Dec 1, 2020·Neural Computation·Asieh Abolpou MofradErik Arntzen
Dec 1, 2019·Neuron·David Tingley, György Buzsáki
Dec 15, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Claire O'CallaghanJames M Shine
Mar 2, 2021·Sleep Advances : a Journal of the Sleep Research Society·Graham FindlayChiara Cirelli
Nov 13, 2020·Cell·James C R WhittingtonTimothy E J Behrens
Feb 8, 2020·Neuron·Karola KaeferJozsef Csicsvari
Apr 14, 2021·Nature Neuroscience·Daniel C McNameeSamuel J Gershman
Apr 22, 2021·Cell Reports·Stephanie M PrinceAnnabelle C Singer
Feb 20, 2020·Neuron·Igor GridchynJozsef Csicsvari
Jun 23, 2021·Nature Neuroscience·L T HuntN Kolling
Aug 7, 2021·Current Opinion in Behavioral Sciences·Dale ZhouDanielle S Bassett
Aug 10, 2021·Neuroscience and Biobehavioral Reviews·Lennart WittkuhnNicolas W Schuck
Sep 15, 2021·ELife·Davide SpallaAlessandro Treves
Sep 16, 2021·PLoS Computational Biology·Kwang Il RyomAlessandro Treves
Sep 28, 2021·ELife·Eric L DenovellisLoren M Frank
Dec 6, 2021·Neuron·Emma L Krause, Jan Drugowitsch
Jan 16, 2022·Neuron·Nils NybergHugo J Spiers