Hippocampal seizure and secondary epileptogenesis in the "kindled" cat preparations

Folia Psychiatrica Et Neurologica Japonica
M Sato

Abstract

The behavioral, electrographic and transference characteristics were investigated in hippocampal kindled cats. All animals developed generalized convulsions following daily hippocampal stimulation (mean 51.8 days). A distinct sequence of behavioral events was observed prior to the seizure and classified into six stages. Motor seizure manifestations appeared along with the emergence of an entirely independent after-discharge and interictal discharge in the bilateral globus pallidus (GP) and amygdala (AM). Secondary site convulsions were triggered with initial stimulation in the GP, contralateral dorsal hippocampus and in most AM sites. This finding suggests that after the primary site was kindled, these previously unstimulated secondary structures attained a response potency equal to that of the primary site. Furthermore, the "all-or nothing" response was confirmed both in the primary and secondary site convulsions.

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Citations

Mar 1, 1993·Electroencephalography and Clinical Neurophysiology·K MutohH Mikawa
Jan 1, 1991·Progress in Neurobiology·E W LothmanJ L Stringer
Jun 3, 2015·Journal of Veterinary Internal Medicine·A PakozdyD Hasegawa
Dec 1, 1985·Journal of Behavior Therapy and Experimental Psychiatry·M J KalsherW R Jankel
Apr 7, 2017·Journal of Veterinary Internal Medicine·S KitzA Pakozdy
Aug 1, 1996·Journal of Medical Ethics·H Watt
Aug 7, 2021·Journal of Feline Medicine and Surgery·Bruno ScaliaGiunio Bruto Cherubini

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