Hippocampal subfield analysis in medication-naïve female patients with major depressive disorder

Journal of Affective Disorders
Kyu-Man HanWoo Suk Tae

Abstract

Hippocampal volume loss is known as the best-replicated finding of structural brain imaging studies on major depressive disorder (MDD). Several evidences suggest localized mechanisms of hippocampal neuroplasticity lead the brain imaging studies on the hippocampus and MDD to perform analyses in the subfield level. The aim of this study was to investigate the differences in total and subfield hippocampal volumes, between medication-naïve female MDD patients and healthy controls, through automated segmentation and volumetric methods. Twenty medication-naïve female patients diagnosed with MDD and 21 age-matched healthy controls, underwent T1-weighted structural magnetic resonance scanning. Total volumes of both hippocampi and subfield regions were calculated by the automated procedure for volumetric measures implemented in FreeSurfer and automated segmentation method by Van Leemput et al. We observed patients to have significantly smaller volumes of the left hippocampus, subiculum, cornu ammonis 2-3, cornu ammonis 4-dentate gyrus, and right subiculum compared to healthy controls. There were no significant predictors for these subfield region volumes among the illness burden-related parameters including duration of illness, number o...Continue Reading

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Citations

Jun 29, 2018·Brain Injury : [BI]·David E RossJan Seabaugh
Jun 9, 2019·The International Journal of Neuropsychopharmacology·Christoph KrausRupert Lanzenberger
Mar 4, 2020·Brain Imaging and Behavior·Masao TakaishiYoshio Hirayasu
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May 14, 2020·Neurotoxicity Research·Gislaine OlescowiczAna Lúcia S Rodrigues
Feb 6, 2019·European Psychiatry : the Journal of the Association of European Psychiatrists·Kyu-Man HanByung-Joo Ham
Apr 30, 2020·International Journal of Molecular Sciences·Asuka KatsukiReiji Yoshimura
May 11, 2021·Frontiers in Aging Neuroscience·Niels HansenRoberto Goya-Maldonado
Jun 15, 2021·Journal of Psychiatric Research·Pablo Patricio Zarate-GarzaRodrigo Enrique Elizondo-Omaña
Dec 24, 2021·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Lorenz LoessnerMarkus Donix

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