Hippocampal volume and memory in narcoleptics with cataplexy

Sleep Medicine
Eun Yeon JooSeung Bong Hong

Abstract

The objective of this study was to investigate the differences in hippocampal volume (HV) between narcoleptics and normal controls and determine if HV is associated with memory function in narcoleptics. Left and right HV and intracranial volumes (ICV) were manually measured and compared between two groups. The study consisted of 36 drug-naïve narcoleptics with cataplexy and 36 age- and sex-matched controls (mean age 29.0 years). All subjects underwent 1.6-mm-thick spoiled gradient recalled magnetic resonance imaging and took the Korean California Verbal Learning Test and the Rey Complex Figure Test to assess verbal and visual memory. The mean ICV was not different between groups (1599.2 cm(3) in narcoleptics vs. 1623.5 cm(3) in controls, p = .450). Bilateral mean HVs were significantly smaller in narcoleptics (left, 2907.2mm(3) in narcoleptics vs. 3092.3mm(3) in controls, p = 0.005; right, 2990.8mm(3) in narcoleptics vs. 3184.3mm(3) in controls, p = 0.004). Significance of HV differences between groups remained after corrections were made for gender, age, and ICV. In narcoleptics, bilateral HV was positively correlated with mean sleep and REM sleep latencies in Multiple Sleep Latency Tests. Absolute memory scores were not diffe...Continue Reading

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Citations

Apr 1, 2015·Neuroscience and Biobehavioral Reviews·Hsu-Huei WengChun-Yuh Yang
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