PMID: 9444493Jan 1, 1997Paper

Hippocampal volume asymmetry and age at illness onset in males with schizophrenia

European Archives of Psychiatry and Clinical Neuroscience
H FukuzakoM Takigawa

Abstract

To determine whether there are disturbances of hippocampal volume asymmetry in schizophrenic patients, we obtained contiguous, 1-mm-thick magnetic resonance images in 28 males with chronic schizophrenia and in 28 age-matched healthy males. The schizophrenic patients showed a bilateral reduction in volume of the hippocampal formation (HF; left 7.0%; right 8.7%). This reduction was significantly associated with the severity of disorganization syndrome (P < 0.0005). A significant asymmetry in the HF volume was found in the control subjects (P = 0.006), but not in the patients (P = 0.40). There was a significant positive correlation between the asymmetry index and the patient's age at the onset of schizophrenia (r = 0.46, P = 0.01). Results indicate that a disturbance in the normal asymmetry of the HF may be a characteristic in schizophrenia, particularly in patients with an early onset of the illness.

References

Aug 1, 1992·Brain : a Journal of Neurology·M J CookJ M Stevens
Sep 20, 1991·Science·L R Squire, S Zola-Morgan
Oct 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·P F Liddle, T R Barnes
Nov 1, 1990·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·T BeckerH Beckmann
Jan 1, 1987·Neuropsychologia·S C SchachterN Geschwind
Jul 1, 1986·Archives of General Psychiatry·J Stevens
Oct 19, 1974·Lancet·E F Torrey, M R Peterson
May 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·S E Chua, P J McKenna
May 1, 1995·The American Journal of Psychiatry·R G PettyR E Powers
Mar 1, 1996·The American Journal of Psychiatry·L K JacobsenJ L Rapoport

❮ Previous
Next ❯

Citations

May 10, 2001·Schizophrenia Research·M E ShentonR W McCarley
Apr 26, 2003·Psychiatry Research·Lara L Davidson, R Walter Heinrichs
Aug 17, 2006·The Australian and New Zealand Journal of Psychiatry·Lisa J PhillipsGregor Berger
Jan 4, 2013·Neurochemical Research·Gonglin HouTi-Fei Yuan
May 10, 2001·Biological Psychiatry·H MatsumotoS Frangou
Jul 13, 2006·Journal of Psychiatric Research·K N ThompsonP D McGorry
Nov 4, 1998·Frontiers in Neuroendocrinology·B CookeS M Breedlove
Mar 24, 2017·Acta Psychiatrica Scandinavica·C NúñezC Stephan-Otto
May 3, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Fulvia AdrianoGianfranco Spalletta
Apr 2, 2002·The British Journal of Psychiatry : the Journal of Mental Science·Steven A ChanceTimothy J Crow
Jan 5, 2000·The British Journal of Psychiatry : the Journal of Mental Science·K RaziL E DeLisi
Dec 24, 2011·International Journal of Adolescent Medicine and Health·Muhammad M TariqTeodor T Postolache

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.