Hippocampus and Parahippocampus Volume Reduction Associated With Impaired Olfactory Abilities in Subjects Without Evidence of Cognitive Decline

Frontiers in Human Neuroscience
Satomi KubotaMasahiko Izumizaki

Abstract

The aim of this study was to investigate the relationship between olfactory recognition and morphological changes in olfactory brain regions including the amygdala, hippocampus, rectus, parahippocampus, orbitofrontal cortex, and medial frontal cortex in 27 elderly subjects and 27 younger healthy controls. The specific aim of the study was to determine which brain areas are associated with the initial decline of olfaction in elderly subjects, which occurs before the onset of dementia. All subjects underwent magnetic resonance imaging to measure anatomical brain volume and cortical thickness, and subjects were assessed using tests of olfactory acuity and cognitive function measured with the Montreal Cognitive Assessment. Overall brain volume reductions were observed in elderly subjects compared with young healthy controls, but only reduction in the volume of the left hippocampus was associated with decreased olfactory ability. The parahippocampus of elderly subjects was not different from that of controls; the extent of the reduction of parahippocampus volume varied among individuals, and reduction in this region was associated with olfactory decline. Similarly, parahippocampus thinning was associated with decreased olfactory fun...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jan 15, 2000·Journal of Neurophysiology·N SobelJ D Gabrieli
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Apr 3, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher Hawkes
Dec 5, 2003·Cerebral Cortex·Bruce FischlAnders M Dale
Apr 9, 2005·Journal of the American Geriatrics Society·Ziad S NasreddineHoward Chertkow
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
Apr 10, 2007·Annual Review of Neuroscience·H EichenbaumC Ranganath
Jul 6, 2010·NeuroImage·Josephine BarnesNick C Fox
Dec 19, 2012·NeuroImage·Chantal Delon-MartinJean-Pierre Royet
Jul 18, 2014·Annual Review of Neuroscience·Wendy A Suzuki, Yuji Naya
Jul 16, 2016·Neuroscience Research·Yuji Naya
Feb 12, 2017·Neurology·Nicolai FranzmeierUNKNOWN Alzheimer's Disease Neuroimaging Initiative (ADNI)
Aug 12, 2017·Journal of Alzheimer's Disease : JAD·Ivan KoychevUNKNOWN Deep and Frequent Phenotyping study team (
Apr 24, 2018·Cell Stem Cell·Gerd KempermannJonas Frisén
Dec 5, 2018·Psychological Medicine·Cassandra M J WannanCali F Bartholomeusz

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Citations

Mar 22, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Xing GaoYongxiang Wei
Mar 27, 2021·Brain and Behavior·Natsuko IizukaMasahiko Izumizaki
May 11, 2021·Frontiers in Molecular Biosciences·Yang LanJia-Xuan Wu
Aug 7, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Haewon RohJong Hyun Kim

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Software Mentioned

FreeSurfer
Freeview
SPSS
SPM12
SPSS Statistics Amos
TkMedit
Segment
Statistical Parametric Mapping 12 ( SPM12
SPM

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