Hippocampus-dependent emergence of spatial sequence coding in retrosplenial cortex

Proceedings of the National Academy of Sciences of the United States of America
Dun MaoBruce L McNaughton

Abstract

Retrosplenial cortex (RSC) is involved in visuospatial integration and spatial learning, and RSC neurons exhibit discrete, place cell-like sequential activity that resembles the population code of space in hippocampus. To investigate the origins and population dynamics of this activity, we combined longitudinal cellular calcium imaging of dysgranular RSC neurons in mice with excitotoxic hippocampal lesions. We tracked the emergence and stability of RSC spatial activity over consecutive imaging sessions. Overall, spatial activity in RSC was experience-dependent, emerging gradually over time, but, as seen in the hippocampus, the spatial code changed dynamically across days. Bilateral but not unilateral hippocampal lesions impeded the development of spatial activity in RSC. Thus, the emergence of spatial activity in RSC, a major recipient of hippocampal information, depends critically on an intact hippocampus; the indirect connections between the dysgranular RSC and the hippocampus further indicate that hippocampus may exert such influences polysynaptically within neocortex.

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Citations

Dec 28, 2018·Human Molecular Genetics·Thomas ArbogastNicholas Katsanis
Nov 2, 2019·Cerebral Cortex·Choijiljav ChinzorigHisao Nishijo
May 30, 2020·Cellular and Molecular Life Sciences : CMLS·Caroline FischerIrmgard Tegeder
Apr 7, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·HaoRan ChangBruce L McNaughton
Sep 22, 2020·Brain and Neuroscience Advances·Alejandra AlonsoLisa Genzel
Jun 5, 2019·Nature Reviews. Neuroscience·James W Antony, Anna C Schapiro
Aug 28, 2020·Frontiers in Computational Neuroscience·Edgar Bermudez-ContrerasAaron Wilber
Jan 3, 2021·Cerebral Cortex·Adam M P MillerDavid M Smith
Dec 15, 2020·Neuroscience and Biobehavioral Reviews·Christopher M DillinghamSeralynne D Vann
Dec 10, 2020·Brain and Neuroscience Advances·Andrew S AlexanderMichael E Hasselmo
Aug 9, 2020·Neuron·Travis D GoodeThomas J McHugh
Dec 7, 2020·Current Opinion in Neurobiology·Ju Lu, Yi Zuo
Jun 12, 2021·IScience·Mai M MorimotoAman B Saleem
Nov 30, 2020·Trends in Cognitive Sciences·Michael PeerRussell A Epstein
Jan 16, 2022·Neuron·Nils NybergHugo J Spiers
Feb 6, 2022·Proceedings of the National Academy of Sciences of the United States of America·Jonas-Frederic SauerMarlene Bartos

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