Hippocampus is necessary for spatial discrimination using distal cue-configuration

Hippocampus
Jangjin Kim, Inah Lee

Abstract

The role of the hippocampus in processing contextual cues has been well recognized. Contextual manipulation often involves transferring animals between different rooms. Because of vague definition of context in such a paradigm, however, it has been difficult to study the role of the hippocampus parametrically in contextual information processing. We designed a novel task in which a different context can be parametrically defined by the spatial configuration of distal cues. In this task, rats were trained to associate two different configurations of distal cue-sets (standard contexts) with different food-well locations at the end of a radial arm. Experiment 1 tested the role of the dorsal hippocampus in retrieving well-learned associations between standard contexts and rewarding food-well locations by comparing rats with neurotoxic lesions in the dorsal hippocampus with controls. We found that the hippocampal-lesioned rats were unable to retrieve the context-place paired associations learned before surgery. To further test the role of the hippocampus in generalizing altered context, in Experiment 2, rats were trained in a task in which modified versions of the standard contexts (ambiguous contexts) were presented, intermixed wit...Continue Reading

References

Apr 1, 1978·Journal of Comparative and Physiological Psychology·G Winocur, J Olds
May 1, 1992·Science·J J Kim, M S Fanselow
Aug 1, 1991·Behavioral Neuroscience·M Good, R C Honey
Aug 1, 1989·Behavioural Brain Research·J W Rudy, R J Sutherland
Dec 1, 1994·Hippocampus·R C O'Reilly, J L McClelland
Dec 6, 2003·The European Journal of Neuroscience·Robin M A HaymanKathryn J Jeffery
Jul 23, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Almira Vazdarjanova, John F Guzowski
Jul 24, 2004·Science·Stefan LeutgebEdvard I Moser
Aug 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pamela J Kennedy, Matthew L Shapiro
Jan 20, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tarek RajjiRobert Greene
Mar 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David M Smith, Sheri J Y Mizumori
Jun 20, 2006·Progress in Neurobiology·Edmund T Rolls, Raymond P Kesner
Aug 22, 2006·Hippocampus·Michael I AndersonKathryn J Jeffery

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Citations

Nov 29, 2012·Nature Neuroscience·Mazen A KheirbekRené Hen
May 1, 2013·Nature Reviews. Endocrinology·Fred Nyberg, Mathias Hallberg
Jul 16, 2014·Neuropharmacology·Fred Nyberg

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