Mar 24, 2020

Hippocampus plays a role in speech feedback processing

BioRxiv : the Preprint Server for Biology
Vincent van de VenI. Christoffels

Abstract

There is increasing evidence that the hippocampus is involved in language production and verbal communication, although little is known about its possible role. According to one view, hippocampus contributes semantic memory to spoken language. Alternatively, hippocampus is involved in the processing the (mis)match between expected sensory consequences of speaking and the perceived speech feedback. In the current study, we re-analysed functional magnetic resonance (fMRI) data of two overt picture-naming studies to test whether hippocampus is involved in speech production and, if so, whether the results can distinguish between a "pure memory" versus an "expectation" account of hippocampal involvement. In both studies, participants overtly named pictures during scanning while hearing their own speech feedback unimpededly or impaired by a superimposed noise mask. Results showed decreased hippocampal activity when speech feedback was impaired, compared to when feedback was unimpeded. Further, we found increased functional coupling between auditory cortex and hippocampus during unimpeded speech feedback, compared to impaired feedback. Finally, we found significant functional coupling between a hippocampal/supplementary motor area (SM...Continue Reading

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Mentioned in this Paper

Y Chromosome
Genome
DNA, Mitochondrial
Nf-at protein, Xenopus
Genomic DNA
Recombinant Proteins
Genes, Y-Linked
Mitochondrial DNA Location
Migration, Cell
Genome, Human

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