Hippocampus-sparing radiotherapy using volumetric modulated arc therapy (VMAT) to the primary brain tumor: the result of dosimetric study and neurocognitive function assessment

Radiation Oncology
Kyung Su KimIn Ah Kim

Abstract

We hypothesized that hippocampal-sparing radiotherapy via volumetric modulated arc therapy (VMAT) could preserve the neurocognitive function (NCF) of patients with primary brain tumors treated with radiotherapy. We reviewed data from patients with primary brain tumors who underwent hippocampal-sparing brain radiotherapy via VMAT between February 2014 and December 2015. The optimization criteria for the contralateral hippocampus was a maximum dose (Dmax) of less than 17 Gy. For NCF evaluations, the Seoul Verbal Learning Test for total recall, delayed recall, and recognition (SVLT-TR, DR, and Recognition) was performed at baseline and at seven months after radiotherapy. A total of 26 patients underwent NCF testing seven months after radiotherapy. Their median age was 49.5 years (range 26-77 years), and 14 (53.8%) had grade III/IV tumors. The median Dmax to the contralateral hippocampus was 16.4 Gy (range 3.5-63.4). The median mean dose to the contralateral hippocampus, expressed as equivalent to a 2-Gy dose (EQD2/2), was 7.4 Gy2 (0.7-13.1). The mean relative changes in SVLT-TR, SVLT-DR, and SVLT-Recognition at seven months compared to the baseline were - 7.7% (95% confidence interval [CI], - 19.6% to 4.2%), - 9.2% (95% CI, - 25.4...Continue Reading

References

Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·June L ChanHoward M Sandler
Jun 21, 2002·Learning & Memory·Andrew C PapanicolaouAnthony A Wright
Nov 15, 2003·Science·Michelle L MonjeTheo D Palmer
Jan 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christina A MeyersMarkus F Renschler
Jan 1, 1996·Applied Neuropsychology·J E MeyersK R Meyers
Mar 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christina A Meyers, Paul D Brown
Apr 21, 2007·International Journal of Radiation Oncology, Biology, Physics·Amol GhiaMinesh P Mehta
Oct 30, 2009·International Journal of Radiation Oncology, Biology, Physics·Rakesh JalaliRajiv Sarin
May 18, 2010·International Journal of Radiation Oncology, Biology, Physics·James C MarshJulius V Turian
Oct 26, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Vinai GondiMinesh P Mehta
Jan 3, 2012·International Journal of Radiation Oncology, Biology, Physics·Vinai GondiWolfgang A Tomé
Jan 15, 2013·International Journal of Radiation Oncology, Biology, Physics·Vinai GondiWolfgang A Tomé
Jun 19, 2013·International Journal of Radiation Oncology, Biology, Physics·Iris C GibbsBrian D Kavanagh
Oct 5, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·M B PinkhamM C Foote
Oct 29, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vinai GondiMinesh P Mehta
Dec 7, 2014·Radiation Oncology·Raphael BodensohnMaximilian Niyazi
Dec 25, 2015·Human Brain Mapping·Marshall A DaltonOlivier Piguet
May 26, 2016·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Kyung Su KimIn Ah Kim
Oct 27, 2016·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·S AdebergS Rieken
Oct 27, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Gregory SmythJames L Bedford

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Citations

Aug 30, 2021·Radiation Oncology·Daniel Felix FleischmannMaximilian Niyazi

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