Hippophae rhamnoides attenuates nicotine-induced oxidative stress in rat liver

Pharmaceutical Biology
Seyithan TaysiMustafa Gul

Abstract

The effects of vitamin E and Hippophae rhamnoides L. (Elaeagnaceae) extract (HRe-1) on nicotine-induced oxidative stress in rat liver were investigated. Four groups, eight rats each, were used in this study, and the supplementation period was 3 weeks. The groups were: nicotine (0.5 mg/kg/day, intraperitoneal (i.p.)); nicotine plus vitamin E (75 mg/kg/day, intragastric (i.g.)); nicotine plus HRe-1 (250 mg/kg/day, i.g.); and the control group. The malondialdehyde and nitric oxide levels, glutathione peroxidase, glutathione S-transferase, glutathione reductase, superoxide dismutase, and total and non-enzymatic superoxide scavenger activities were measured spectrophotometrically in supernatants of the tissue homogenates. Nicotine increased the malondialdehyde level in liver tissue compared with control. This nicotine-induced increase in lipid peroxidation was prevented by both vitamin E and HRe-1. Superoxide dismutase activity was higher in the nicotine plus vitamin E-supplemented group compared with nicotine and control groups. Glutathione reductase activity was higher in the nicotine group compared with the control group. However, glutathione peroxidase activity in the control group was higher than the levels in the nicotine, and...Continue Reading

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Citations

Oct 25, 2012·Endocrinology·Theodore C FriedmanAmiya P Sinha-Hikim
Oct 4, 2011·Journal of Ethnopharmacology·Geetha Suryakumar, Asheesh Gupta
Oct 2, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ji-Yin ZhouSheng-Ya Zeng
Mar 31, 2021·Critical Reviews in Food Science and Nutrition·Kewen WangXiaojun Liao

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