His-87 ligand in mitoNEET is crucial for the transfer of iron sulfur clusters from mitochondria to cytosolic aconitase

Biochemical and Biophysical Research Communications
Guoqiang TanJianxin Lyu

Abstract

MitoNEET is the first identified iron sulfur protein that located in the mitochondrial outer membrane. We showed that knockdown of mitoNEET did not affect the iron sulfur protein expression in mitochondria and cytoplasm, but significantly reduced the cytosolic aconitase activity. The reduction of aconitase activity was rescued by transfection of wild type mitoNEET, but not by mitoNEET mutants H87C and H87S. Our results confirm the observation that mitoNEET is important in transferring the iron sulfur clusters to the cytosolic aconitase in living cells and the His-87 ligand in mitoNEET plays important role in this process.

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Jan 6, 2017·Journal of the American Chemical Society·Marie BergnerFranc Meyer
Apr 21, 2017·PloS One·Ola KarmiRon Mittler
Jun 27, 2017·Journal of the American Chemical Society·Francesca CamponeschiLucia Banci
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Mar 21, 2018·Scientific Reports·Soham SenguptaRon Mittler
Jan 23, 2021·International Journal of Molecular Sciences·Woon-Man Kung, Muh-Shi Lin

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