His-Asp phosphotransfer signal transduction

Journal of Biochemistry
T Mizuno

Abstract

In general, protein phosphorylation is one of the most widely used mechanisms for regulating biological processes, including intracellular signal transduction. In eukaryotes, the cascades of protein phosphorylation and dephosphorylation events involving a number of protein tyrosine or serine/threonine kinases have been well studied. In contrast, recent intensive studies revealed that bacteria have devised a quite different phosphotransfer signaling mechanism for eliciting a variety of adaptive responses to their environment. Such a bacterial signal transduction mechanism was originally referred to as a "two-component regulatory system." The mode of molecular communication between a "sensor kinase" and its cognate phospho-accepting "response regulator" is principally based on histidine-to-aspartate (His-Asp) phosphotransfer. In Escherichia coli, for example, at least 30 different sensor-regulator pairs operate in a wide variety of adaptive responses. This particular signal transduction mechanism was once thought to be restricted to prokaryotes. However, many instances have recently been uncovered in diverse eukaryotic species. Furthermore, recent studies suggested that the molecular mechanism underlying the bacterial signal tran...Continue Reading

Citations

Jan 13, 2000·Biochemical and Biophysical Research Communications·B P MooneyD D Randall
Nov 8, 2002·Journal of Molecular Biology·Steven L Porter, Judith P Armitage
May 23, 2001·Microbes and Infection·M FoussardJ Samama
Feb 25, 2000·The International Journal of Biochemistry & Cell Biology·P G Besant, P V Attwood
Jul 4, 2001·Trends in Plant Science·T Schmülling
Dec 23, 1999·Current Opinion in Microbiology·M J Ward, D R Zusman
Mar 11, 2009·Biochemistry·Uchechi E Ukaegbu, Amy C Rosenzweig
Aug 14, 2009·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Kai IshidaTakeshi Mizuno
Jan 27, 2005·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Keisuke HamadaToshio Hakoshima
Jul 24, 2007·Journal of Bacteriology·William R SchwanAlan J Wolfe
Jun 1, 2002·Microbiology and Molecular Biology Reviews : MMBR·Stefan Hohmann
Dec 15, 2010·Bioscience, Biotechnology, and Biochemistry·Kai IshidaTakeshi Mizuno
Oct 26, 2001·Bioscience, Biotechnology, and Biochemistry·A ImamuraT Mizuno
Feb 25, 2003·Bioscience, Biotechnology, and Biochemistry·Norihito NakamichiTakeshi Mizuno
May 2, 2003·Bioscience, Biotechnology, and Biochemistry·Norihito NakamichiTakeshi Mizuno
Aug 24, 2004·Bioscience, Biotechnology, and Biochemistry·Daisuke HagiwaraTakeshi Mizuno
Dec 27, 2005·Bioscience, Biotechnology, and Biochemistry·Takeshi Mizuno
Oct 8, 2008·Bioscience, Biotechnology, and Biochemistry·Daisuke HagiwaraTakeshi Mizuno
Jan 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Eric Batchelor, Mark Goulian
Mar 19, 2014·Applied Microbiology and Biotechnology·Zheng-Liang WangMing-Guang Feng

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