Hispidulin, a constituent of Clerodendrum inerme that remitted motor tics, alleviated methamphetamine-induced hyperlocomotion without motor impairment in mice

Journal of Ethnopharmacology
Wei-Jan HuangLih-Chu Chiou

Abstract

Previously, we found a patient with an intractable motor tic disorder that could be ameliorated by the ground leaf juice of Clerodendrum inerme (CI). Furthermore, the ethanol extract of CI leaves effectively ameliorated methamphetamine-induced hyperlocomotion (MIH) in mice, an animal model mimicking the hyper-dopaminergic status of tic disorders/Tourette syndrome, schizophrenia, or obsessive-compulsive disorder. Here, we for the first time identified a constituent able to reduce MIH from the CI ethanol extract that might represent a novel lead for the treatment of such disorders. The ethanol extract of CI was sub-divided into n-hexane, dichloromethane, n-butanol and water fractions. Using MIH alleviation as a bioassay, active compounds were identified in these fractions using silica gel chromatography, recrystallization and proton NMR spectroscopy. The dichloromethane and n-hexane fractions were active in the bioassay. Further subfractionation and re-crystallization resulted in an active compound that was identified to be hispidulin by proton NMR spectroscopy. Hispidulin significantly alleviated MIH in mice at doses that did not affect their spontaneous locomotor activity or performance in the rotarod test, a measure for motor ...Continue Reading

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Citations

Apr 20, 2016·Frontiers in Neuroscience·Ester NespoliAndrea G Ludolph
Nov 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Letizia PolitoAndrea Bolognesi
Nov 9, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Liang-Chieh ChenWei-Jan Huang
Nov 12, 2017·British Journal of Pharmacology·Marco TrevenMargot Ernst

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