Hispolon as an inhibitor of TGF-β-induced epithelial-mesenchymal transition in human epithelial cancer cells by co-regulation of TGF-β-Snail/Twist axis

Oncology Letters
Darong HongJong-Ho Kim

Abstract

Hispolon (HPL), isolated from Phellinus linteus, has been used to treat various types of pathology, including inflammation, gastroenteric disorders, lymphatic diseases and numerous cancer subtypes. HPL has previously been reported to demonstrate a significant therapeutic efficacy against various types of cancer cells, including melanoma, leukemia, hepatocarcinoma, bladder and gastric cancer cells. However, its potential role in the epithelial-mesenchymal transition (EMT) has not been demonstrated. The present study investigated the effects of HPL on the EMT. Transforming growth factor β (TGF-β) induced enhanced cell migration and invasion, EMT-associated phenotypic changes. In the present study, HPL recovered the reduction of E-cadherin expression level in TGF-β treated cancer cells, which was regulated by the expression of Snail and Twist. HPL downregulated Snail and Twist, an effect that was enhanced by TGF-β. These findings provide novel evidence that HPL suppresses cancer cell migration and invasion by inhibiting EMT. Therefore, HPL may be a potent anticancer agent, inhibiting metastasis.

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Citations

May 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wenhua ChenLingchuan Xu
Dec 18, 2019·Cells·Joanna BoguslawskaAgnieszka Piekielko-Witkowska
Jun 21, 2020·Anti-cancer Agents in Medicinal Chemistry·Muhammad T IslamMohammad S Mubarak
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kuan-Fu LiaoSheng-Chun Chiu

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