PMID: 9534890Apr 16, 1998Paper

Histamine and cutaneous nociception: histamine-induced responses in patients with atopic eczema, psoriasis and urticaria

Acta Dermato-venereologica
G HeyerH O Handwerker

Abstract

Having observed altered itch and flare reactions after histamine application in patients with atopic eczema, we tried to determine these reactions in patients with urticaria and psoriasis. We investigated 16 healthy non-atopic subjects, 16 atopics in an eczema-free interval, 16 with acute atopic eczema, 16 with urticaria and 16 with psoriasis. Histamine was iontophoretically applied. The resulting sensations were rated on a visual analogue scale. Flare areas were measured 6 min after stimulation. Itch ratings of urticaria and psoriasis patients did not differ significantly from controls, whereas both atopic groups, regardless of acute or symptom-free state, reported significantly reduced intensity of itching. Flares were significantly diminished in all subjects with acute skin disease (psoriasis, urticaria and atopic eczema), regardless of diagnosis. However, flares were "normal" in symptom-free atopics and were not significantly different from controls. In conclusion, all "acute" patients showed a diminished axon-reflex function, possibly due to a downregulation of C-fiber responsiveness to histamine or an increased turnover rate of inflammatory mediators. Both atopic groups reported weaker itching, suggesting altered central ...Continue Reading

Citations

Feb 20, 2003·European Journal of Pharmacology·Tatiana R LavichMarco A Martins
Dec 22, 1999·Clinical and Experimental Dermatology·J L Rees, A Laidlaw
Aug 21, 2007·Life Sciences·Elizabeth TingClaudia H Tambeli
Jan 22, 2008·European Journal of Pain : EJP·Gudrun SchneiderMatthias Weckesser
Apr 14, 2010·Allergy·J Buddenkotte, M Steinhoff
Nov 20, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sumit PaliwalSamir Mitragotri
Mar 26, 1999·The Journal of Dermatology·G R Heyer, O P Hornstein
Dec 29, 2004·Pain·Akihiko IkomaMartin Schmelz
Mar 17, 2010·Pain·Antoinette I M van LaarhovenAndrea W M Evers
Sep 18, 2007·Current Opinion in Allergy and Clinical Immunology·Ferda CevikbasMartin Steinhoff
Jul 19, 2018·Experimental Dermatology·Piet E J van ErpDenise Falcone
Oct 4, 2006·Physiological Reviews·Dirk RoostermanMartin Steinhoff
Aug 27, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Maristella AdamiHolger Stark

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